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Food insecurity—the economic and social condition of limited or uncertain access to adequate food—is high on the agenda.1 In Europe, estimates from Eurostat in 2020 show that 7% of households with children are food insecure.2 There is a get lasix prescription worry that the corresponding figures for 2021 may be even higher as the hypertension medications lasix has led to increased unemployment and economic uncertainty, processes that likely exacerbate food insecurity.3 4 The fact that so many children experience insecure access to food is important in its own right, but food insecurity is also associated with long-term adverse outcomes related to, for example, education and nutrition.5 6In a timely new study, Men et al7 examine the association between food insecurity and mental health problems among children and young adults. Using large-scale Canadian survey data on more than 55 000 individuals, they document that food insecurity is associated with worse mental health, and that the association is graded with more severe food insecurity associated with progressively worse health. The study includes overall measures of mental health, but also more specific measures related to depression, anxiety and suicidal ideation.Beyond the immediate relevance of the topic, Men et al7 address dimensions of disadvantage that go beyond standard measures of socioeconomic status such as income and poverty, and it is also interesting to see such patterns in a country with universal healthcare and a safety net meant get lasix prescription to buffer some of the disadvantages of poor income. Men et al7 also found a strong association between food insecurity and risk of mental health problems, net of household income and other socioeconomic factors. This highlights get lasix prescription an additional point.

Even though childhood food insecurity is closely linked to poverty, food insecurity may be high even among families above poverty thresholds.Men and colleagues mention social disorganisation within the family as a potential explanation of why the relationship between household insecurity and mental health exists even after controlling for income. Other factors, such as high cost of living in certain areas (ie, large cities), may make get lasix prescription it difficult to get by even with a decent income. As such geography may be a relevant factor. Parental unemployment and other abrupt changes get lasix prescription such as divorce, or disability among family members, are additional factors that could contribute to food insecurity. Importantly, these risk factors are much more likely to affect low-income families.8 Even among those entitled to benefits, there might be delays in receiving these, with consequences for a family’s food security.

Typically, family poverty is often measured annually, but such aggregated measures might not capture the income volatility experienced by many low-income families.A key limitation of the study is the cross-sectional nature of the data, which makes the interpretation open to reverse causation get lasix prescription. For example, prior research has revealed a plethora of factors that predict food insecurity, such as mother’s health, substance abuse, family instability and immigrant background.5 Thus, the path from food insecurity to mental health might not be as straightforward as we might expect, as there could be other factors—often less easily measured—that account for part of the association. However, the authors acknowledge this, and one study get lasix prescription can only do so much. Instead, future research should also apply (quasi)experimental approaches to get closer to causal estimates.Future research could also benefit from a comparative perspective. The rate of food insecurity varies considerably across countries, but we know less about whether the consequences of food insecurity for children and youth also differ across get lasix prescription countries.

Previous research has shown that the relationship between parental income and children’s adult attainments and intergenerational mobility varies across countries, with less adverse consequences in more egalitarian and universal welfare states.9 For the current topic, the primary goal of welfare states should be to limit the prevalence of food insecurity among children. However, it is important to know whether welfare states also cushion the negative repercussions among those children who still face insecure access to food while growing up.Ethics statementsPatient consent for publicationNot required.Recent evidence of continuing inequalities by educational level in disability in Europe is disappointing. Further socioeconomic measures might reveal greater inequalities get lasix prescription. Conclusions are limited by differences in wording used to establish disability. Assuming that there is inequity behind these inequalities, this, along with the adverse effects of the hypertension medications lasix, reinforces the need get lasix prescription for multisectoral action, collaboration and cooperation.Rubio Valverde et al1 show us that inequalities in disabilities in Europe have not improved between 2002 and 2017.

They included a wide age range (30–79 years) and 26 countries. They used get lasix prescription two surveys, the European Union Statistics on Income and Living (EU-SILC) and the European Social Survey. The disability measure was the Global Activity Limitation Indicator (GALI), a self-report of being limited in activities ‘people usually do’ in the past 6 months.2 The former survey indicated an increase in gap between low and high education groups, with the more educated experiencing reduced prevalence of disability, and the latter survey no discernible trend. Inequalities have been the subject of discussion for decades so it is disappointing to find get lasix prescription this.Three aspects of the paper caught my attention. This is one of a long series of analyses by Mackenbach and his team which use education as the socioeconomic indicator.

Their reasons for doing this are that they judge educational measures get lasix prescription to be most comparable across countries, that it may be a starting point for several pathways and reverse causation is unlikely.3 However, it may not be the socioeconomic indicator most strongly related to disability and may underestimate the importance of socioeconomic status. For example, in the English Longitudinal Study of Ageing, absolute differences in healthy life expectancy were greater for wealth categories than for education or social class whereas in the USA’s Health and Retirement Study both wealth and education were strong.4 Marmot’s example of a Glasgow male shows how education, occupation and material resource all play a part.5Marmot is also talking about ‘equity’ whereas Rubio Valverde’s paper refers to inequality. To know that there are these inequalities is the starting point but the prompt to action is inequity get lasix prescription. Not a new topic, of course, but one that has become highly visible with the hypertension medications lasix. The WHO report judges that ‘failure to anticipate and avoid the resulting unwanted scenarios in the short and medium terms has led to get lasix prescription a major risk both of exacerbating health, social and economic inequities in the long term and of giving rise to new vulnerabilities within the population’6 (p 1).

People with learning and other disabilities have been at higher risk of death. In England, as of get lasix prescription November 2020, 60% of hypertension medications deaths were to people with disabilities.7 hypertension medications is leaving some people with reduced long-term health which may lead to reduced earning capacity or mobility6 (p 33). Also, new hardship is arising because of the economic and social restrictions. The corollary of the two-way impact of socioeconomic inequities on the lasix and the lasix on the inequities is the need for multisectoral policies affecting people’s access to essential care and health services, providing economic security and ensuring that decision-making is an inclusive process6 (p 14). We need ‘commitment to social justice and get lasix prescription putting equity of health and wellbeing at the heart of all policy making’8 (p 64).

Marmot is addressing socioeconomic inequity and those relating to ethnicity, age and gender.The third aspect of the paper is the variability between countries and between surveys in the graphs of disability prevalence over time. Both the get lasix prescription levels and shapes vary. Rubio Valverde et al highlight this and, not finding clear geographical patterns, fall back on overall averages. Some of this heterogeneity arises from variation in the GALI wording used in EU-SILC and they have tried to take some get lasix prescription account of this. There are now several multicountry studies and families of cohort studies which aim to harmonise measures within their group.

Methods are being developed to harmonise when measures are different9 but Rubio Valverde’s paper highlights get lasix prescription how differences in measurement can hamper conclusions about risks. Being self-report, and depending on what people consider to be usual, one can expect some variation by culture and age and gender. However, it is likely that some of it arises from the context in get lasix prescription which people live. Their country’s health services, policy and environment. It would be get lasix prescription instructive to learn more about this and see what we can learn from each other.

During the lasix, countries have taken very different paths to deal with the hypertension lasix and its effects. Collaborative research is get lasix prescription common in epidemiology. In the economic and political world, sometimes it feels as if the terms ‘cooperation’ and ‘collaboration’ are undervalued. My wish is to see them given greater prominence.Ethics statementsPatient consent for publicationNot required..

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The former host of America's Most Wanted shared his belief that Brian Laundrie's family could have bought read more him time to flee as authorities investigate the death of Gabby Petito.In an interview with CNN, John Walsh said he doesn't think the 23-year-old was ever in the Florida wildlife preserve where can you get lasix without a prescription authorities have been searching for him.His parents reported on Friday, Sept. 17 that can you get lasix without a prescription they hadn't seen their son since Tuesday, Sept. 14.The FBI named Laundrie a can you get lasix without a prescription person of interest in the homicide of Petito, age 22, who was from Blue Point in Suffolk County. The couple had been traveling across the country in Petito's van before her disappearance.

Laundrie returned can you get lasix without a prescription home to North Port, in Sarasota County, Florida on Wednesday, Sept. 1 without Petito and can you get lasix without a prescription did not cooperate with investigators after Petito's family reported her missing on Saturday, Sept. 11.Petito's remains were discovered in can you get lasix without a prescription a Wyoming national park on Sunday, Sept. 19.In the interview with CNN, Walsh was critical of the statement from Laundrie's parents that they found their son's car at the large Florida wildlife preserve they can you get lasix without a prescription said he had visited."My philosophy is he never went to the swamp," Walsh said.

"His parents and the lawyer on the phone bought him four days to get out in front of this." Walsh also questioned whether anyone has seen any proof that Laundrie was in the home when his lawyer had previously said he was. Click here to sign up for Daily Voice's free can you get lasix without a prescription daily emails and news alerts.Former President Donald Trump is going on the offensive, filing a $100 million lawsuit against the New York Times and his niece, Mary Trump, as he seeks to withhold disclosing his tax information.Trump filed the lawsuit in the Hudson Valley accusing both his niece and the Times of “tortiously breaching and/or interfering with his contractual rights and otherwise maliciously conspiring against him” as they continue requesting a report on his 2018 taxes. The lawsuit alleges that the Times coerced Mary Trump to "smuggle records out of her attorney’s office and turn them over to the Times,” despite a confidentiality agreement.It is alleged can you get lasix without a prescription that Mary Trump had access to "more than 40,000 pages of highly sensitive, proprietary, private and confidential documents, including, but not limited to, financial documents, accountings, tax records, income tax returns, bank statements, legal documents, and other related documents.” The lawsuit claims the documents were deemed confidential as a part of a settlement agreement. €œThe defendants engaged in an insidious plot to obtain confidential and highly-sensitive records which they exploited for their own benefit and utilized as a means of falsely legitimizing their publicized works,” the lawsuit filed in Dutchess County states.“The defendants’ actions were motivated by a personal vendetta and their desire to gain fame, notoriety, acclaim and a financial windfall and were further intended to advance their political agenda.” In the lawsuit, which names Mary Trump, Times reporters David Barstow, Susanne Craig, and Russ Buettner as defendants, the embattled former president is demanding at least $100 million in alleged damages.Mary Trump, the daughter of the former president’s late older brother Fred Trump, Jr., dismissed the lawsuit in a statement, calling the move an act of desperation as the disgraced former president continues to avoid disclosing his taxes.“I think he is a loser, and he is going to throw anything against the wall he can.

It's desperation,” she can you get lasix without a prescription stated. €œThe walls can you get lasix without a prescription are closing in and he is throwing anything against the wall that he thinks will stick. As is always the case with Donald, he'll try and change the subject.”In a separate statement, the Times - which earned a Pulitzer Prize award can you get lasix without a prescription for its coverage of Trump’s questionable finances in 2019 - also called out the former president’s move to file a multi-million dollar lawsuit.
"Coverage of Donald Trump's taxes helped inform citizens through meticulous reporting on a subject of overriding public interest,” a spokesperson said. This lawsuit is an attempt to silence independent news organizations and we plan to vigorously defend against it.” Click here to sign up for Daily Voice's free daily emails and news alerts..

The former host of America's Most Wanted shared http://mangomgmt.co.uk/blog/blog-full-width-textual/ his belief that Brian Laundrie's family could have bought him time to flee as authorities investigate the death of Gabby Petito.In an interview with CNN, John Walsh said he doesn't think the 23-year-old was ever in the Florida wildlife preserve where authorities get lasix prescription have been searching for him.His parents reported on Friday, Sept. 17 that they hadn't seen their get lasix prescription son since Tuesday, Sept. 14.The FBI named Laundrie a person of get lasix prescription interest in the homicide of Petito, age 22, who was from Blue Point in Suffolk County. The couple had been traveling across the country in Petito's van before her disappearance.

Laundrie returned home to North Port, in Sarasota County, get lasix prescription Florida on Wednesday, Sept. 1 without Petito and did not cooperate with investigators after Petito's family reported her missing get lasix prescription on Saturday, Sept. 11.Petito's remains were discovered in a Wyoming national park on get lasix prescription Sunday, Sept. 19.In the interview with CNN, Walsh was critical of the statement from Laundrie's parents get lasix prescription that they found their son's car at the large Florida wildlife preserve they said he had visited."My philosophy is he never went to the swamp," Walsh said.

"His parents and the lawyer on the phone bought him four days to get out in front of this." Walsh also questioned whether anyone has seen any proof that Laundrie was in the home when his lawyer had previously said he was. Click here to sign up for Daily Voice's free daily emails and news alerts.Former President Donald Trump is going on the offensive, filing a $100 million lawsuit against the New York Times and his niece, Mary Trump, as he seeks to withhold disclosing his tax information.Trump filed the lawsuit get lasix prescription in the Hudson Valley accusing both his niece and the Times of “tortiously breaching and/or interfering with his contractual rights and otherwise maliciously conspiring against him” as they continue requesting a report on his 2018 taxes. The lawsuit alleges that the Times coerced Mary Trump to "smuggle records out of her attorney’s office and turn them over to the Times,” despite a confidentiality agreement.It is alleged that Mary Trump had access to "more than 40,000 pages of highly sensitive, proprietary, private and confidential documents, including, but not limited to, financial documents, accountings, tax records, income tax get lasix prescription returns, bank statements, legal documents, and other related documents.” The lawsuit claims the documents were deemed confidential as a part of a settlement agreement. €œThe defendants engaged in an insidious plot to obtain confidential and highly-sensitive records which they exploited for their own benefit and utilized as a means of falsely legitimizing their publicized works,” the lawsuit filed in Dutchess County states.“The defendants’ actions were motivated by a personal vendetta and their desire to gain fame, notoriety, acclaim and a financial windfall and were further intended to advance their political agenda.” In the lawsuit, which names Mary Trump, Times reporters David Barstow, Susanne Craig, and Russ Buettner as defendants, the embattled former president is demanding at least $100 million in alleged damages.Mary Trump, the daughter of the former president’s late older brother Fred Trump, Jr., dismissed the lawsuit in a statement, calling the move an act of desperation as the disgraced former president continues to avoid disclosing his taxes.“I think he is a loser, and he is going to throw anything against the wall he can.

It's desperation,” she get lasix prescription stated. €œThe walls are closing in and he is throwing anything against the wall that get lasix prescription he thinks will stick. As is always the case with Donald, he'll try and change the subject.”In a separate statement, the Times - which earned a Pulitzer Prize award for its coverage of Trump’s questionable finances in 2019 - also called out the former president’s move to file a multi-million dollar lawsuit.
"Coverage of Donald Trump's taxes helped inform get lasix prescription citizens through meticulous reporting on a subject of overriding public interest,” a spokesperson said. This lawsuit is an attempt to silence independent news organizations and we plan to vigorously defend against it.” Click here to sign up for Daily Voice's free daily emails and news alerts..

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To be assured consideration, comments and why do you have to take potassium with lasix recommendations must be submitted in any one http://robertflannagan.com/?p=8 of the following ways. 1. Electronically.

You may send your comments electronically to why do you have to take potassium with lasix http://www.regulations.gov. Follow the instructions for “Comment or Submission” or “More Search Options” to find the information collection document(s) that are accepting comments. 2.

By regular why do you have to take potassium with lasix mail. You may mail written comments to the following address. CMS, Office of Strategic Operations and Regulatory Affairs, Division of Regulations Development, Attention.

Document Identifier/OMB why do you have to take potassium with lasix Control Number. CMS-P-0015A, Room C4-26-05, 7500 Security Boulevard, Baltimore, Maryland 21244-1850. To obtain copies of a supporting statement and any related forms for the proposed collection(s) summarized in this notice, you may make your request using one of following.

1. Access CMS' website address at website address at https://www.cms.gov/​Regulations-and-Guidance/​Legislation/​PaperworkReductionActof1995/​PRA-Listing.html. Start Further Info William N.

Parham at (410) 786-4669. End Further Info End Preamble Start Supplemental Information Contents This notice sets out a summary of the use and burden associated with the following information collections. More detailed information can be found in each collection's supporting statement and associated materials (see ADDRESSES).

CMS-10450 Consumer Assessment of Healthcare Providers and Systems (CAHPS) Survey for Merit-based Incentive Payment Systems (MIPS) CMS-10249 Administrative Requirements for Section 6071 of the Deficit Reduction Act Under the PRA (44 U.S.C. 3501-3520), federal agencies must obtain approval from the Office of Management and Budget (OMB) for each collection of information they conduct or sponsor. The term “collection of information” is defined in 44 U.S.C.

3502(3) and 5 CFR 1320.3(c) and includes agency requests or requirements that members of the public submit reports, keep records, or provide information to a third party. Section 3506(c)(2)(A) of the PRA requires federal agencies to publish a 60-day notice in the Federal Register concerning each proposed collection of information, including each proposed extension or reinstatement of an existing collection of information, before submitting the collection to OMB for approval. To comply with this requirement, CMS is publishing this notice.

Information Collection 1. Type of Information Collection Request. Extension of a currently approved Information Collection.

Title of Information Collection. Consumer Assessment of Healthcare Providers and Systems (CAHPS) Survey for Merit-based Incentive Payment Systems (MIPS). Use.

CMS is submitting updates to one information collection request associated with the CAHPS for MIPS survey. The CAHPS for MIPS survey is used in the Quality Payment Program (QPP) to collect data on fee-for-service Medicare beneficiaries' experiences of care with eligible clinicians participating in MIPS and is designed to gather only the necessary data that CMS needs for assessing physician quality performance, and related public reporting on physician performance, and should complement other data collection efforts. The survey consists of the core Agency for Healthcare Research and Quality (AHRQ) CAHPS Clinician &.

Group Survey, version 3.0, plus additional survey questions to meet CMS's information and program needs. The survey information is used for quality reporting, the Care Compare website, and annual statistical experience reports describing MIPS data for all MIPS eligible clinicians. This 2021 information collection request addresses changes to the CAHPS for MIPS Survey associated with the CY 2021 Physician Fee Schedule (PFS) final rule.

In order to address the increased use of telehealth care due to the Public Health Emergency (PHE) for hypertension medications, an additional question is added to the CAHPS for MIPS survey to integrate one telehealth item to assess the patient-reported usage of telehealth services. In addition, the cover page of the CAHPS for MIPS Survey is revised to include a reference to care in telehealth settings. The CAHPS for MIPS survey results in burden to three different types of entities.

Groups and virtual groups, vendors, and beneficiaries associated with administering the survey. Virtual groups are subject to the same requirements as groups. Therefore, we will refer only to groups as an inclusive term for both unless otherwise noted.

The estimated time to administer the 2021 CAHPS for MIPS survey has increased from 12.9 minutes to 13.1 minutes. However, there was an overall decrease in burden as the number of respondents decreased. Form Number.

CMS-10450 (OMB control number. 0938-1222). Frequency.

Yearly. Affected Public. Business or other for-profits and Not-for-profit institutions and Individuals and Households.

Number of Respondents. 30,249. Total Annual Responses.

30,249. Total Annual Hours. 6,902 (For policy questions regarding this collection contact Alesia Hovatter at 410-786-6861.) 2.

Type of Information Collection Request. Revision of a currently approved collection. Title of Information Collection.

Administrative Requirements for Section 6071 of the Deficit Reduction Act. Use. State Operational Protocols should provide enough information such that.

The CMS Start Printed Page 23385Project Officer and other federal officials may use it to understand the operation of the demonstration, prepare for potential site visits without needing additional information, or both. The State Project Director can use it as the manual for program implementation. And external stakeholders may use it to understand the operation of the demonstration.

The financial information collection is used in our financial statements and shared with the auditors who validate CMS' financial position.

The term get lasix prescription “collection of information” is defined in 44 U.S.C. 3502(3) and 5 CFR 1320.3(c) and includes agency requests or requirements that members of the public submit reports, keep records, or provide information to a third party. Section 3506(c)(2)(A) of the PRA requires federal agencies to publish a 60-day notice in the Federal Register concerning each proposed collection of information, including each proposed extension or reinstatement of an existing collection of information, before submitting the collection to OMB for approval.

To comply with get lasix prescription this requirement, CMS is publishing this notice. Information Collection 1. Type of Information Collection Request.

Extension of a currently approved Information get lasix prescription Collection. Title of Information Collection. Consumer Assessment of Healthcare Providers and Systems (CAHPS) Survey for Merit-based Incentive Payment Systems (MIPS).

Use. CMS is submitting updates to one information collection request associated with the CAHPS for MIPS survey. The CAHPS for MIPS survey is used in the Quality Payment Program (QPP) to collect data on fee-for-service Medicare beneficiaries' experiences of care with eligible clinicians participating in MIPS and is designed to gather only the necessary data that CMS needs for assessing physician quality performance, and related public reporting on physician performance, and should complement other data collection efforts.

The survey consists of the core Agency for Healthcare Research and Quality (AHRQ) CAHPS Clinician &. Group Survey, version 3.0, plus additional survey questions to meet CMS's information and program needs. The survey information is used for quality reporting, the Care Compare website, and annual statistical experience reports describing MIPS data for all MIPS eligible clinicians.

This 2021 information collection request addresses changes to the CAHPS for MIPS Survey associated with the CY 2021 Physician Fee Schedule (PFS) final rule. In order to address the increased use of telehealth care due to the Public Health Emergency (PHE) for hypertension medications, an additional question is added to the CAHPS for MIPS survey to integrate one telehealth item to assess the patient-reported usage of telehealth services. In addition, the cover page of the CAHPS for MIPS Survey is revised to include a reference to care in telehealth settings.

The CAHPS for MIPS survey results in burden to three different types of entities. Groups and virtual groups, vendors, and beneficiaries associated with administering the survey. Virtual groups are subject to the same requirements as groups.

Therefore, we will refer only to groups as an inclusive term for both unless otherwise noted. The estimated time to administer the 2021 CAHPS for MIPS survey has increased from 12.9 minutes to 13.1 minutes. However, there was an overall decrease in burden as the number of respondents decreased.

Form Number. CMS-10450 (OMB control number. 0938-1222).

Business or other for-profits and Not-for-profit institutions and Individuals and Households. Number of Respondents. 30,249.

Total Annual Responses. 30,249. Total Annual Hours.

6,902 (For policy questions regarding this collection contact Alesia Hovatter at 410-786-6861.) 2. Type of Information Collection Request. Revision of a currently approved collection.

Title of Information Collection. Administrative Requirements for Section 6071 of the Deficit Reduction Act. Use.

State Operational Protocols should provide enough information such that. The CMS Start Printed Page 23385Project Officer and other federal officials may use it to understand the operation of the demonstration, prepare for potential site visits without needing additional information, or both. The State Project Director can use it as the manual for program implementation.

And external stakeholders may use it to understand the operation of the demonstration. The financial information collection is used in our financial statements and shared with the auditors who validate CMS' financial position. The Money Follows the Person Rebalancing Demonstration (MFP) Finders File, MFP Program Participation Data file, and MFP Services File are used by the national evaluation contractor to assess program outcomes while we use the information to monitor program implementation.

The MFP Quality of Life data is used by the national evaluation contractor to assess program outcomes. The evaluation is used to determine how participants' quality of life changes after transitioning to the community. The semi-annual progress report is used by the national evaluation contractor and CMS to monitor program implementation at the grantee level.

The revisions aim to reduce the reporting burden by presenting a substantially revised and shorted version of the semi-annual progress report. The budget workbook has also been revised to combine two earlier reporting forms. Form Number.

CMS-10249 (OMB control number. 0938-1053). Frequency.

Yearly, quarterly, and semi-annually. Affected Public. State, Local, or Tribal Governments.

Number of Respondents. 42. Total Annual Responses.

(For policy questions regarding this collection contact Todd Wilson at 410-786-3409.) Start Signature Dated.

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New data, in addition to analyses by Learn More Here scientists at the Food and Drug Administration, may take some of the shine off Merck’s experimental hypertension medications pill, molnupiravir.On Friday, the drug maker released full results from its study of the pill, molnupiravir, showing it reduced the risk of hospitalization by 30%, down from a decrease of 50% seen lasix med in an earlier analysis. In the 1,433-patient study, fewer patients died when they received the treatment. There were nine deaths in the placebo group in the final analysis, and one in the molnupiravir group.The data were released as the FDA published its own analysis of molnupiravir ahead of a meeting of advisers being convened by the agency to vote on whether the medicine’s benefits outweigh its risks.advertisement In that analysis, FDA researchers seemed to favor the authorization of molnupiravir but lasix med raised concerns that could mean people who are at lower risk from the disease would not be offered the pill.

Alex Hogan/STAT The fate of molnupiravir — developed in partnership between Merck and Ridgeback Therapeutics — is important for both society’s battle against hypertension medications and Merck’s financial fortunes. Experts say that an easy-to-give, oral treatment that keeps people who contract the hypertension lasix from being hospitalized or dying would go a long way toward helping society return to normal lasix med. Existing pills, such as hydroxychloroquine or ivermectin, have failed to deliver convincing results.

Monoclonal antibodies treatments, though very effective, must be given as shots or intravenous infusions.advertisement Pfizer recently released results on lasix med its own hypertension medications pill, showing an 89% decrease in hospitalizations in an interim analysis.As governments buy large amounts of both pills, the financial stakes could be enormous. During its October earnings call, Merck said molnupiravir could generate between $500 million and $1 billion this year and between $5 billion and $7 billion next year, according to a transcript STAT obtained through Senteio, a financial database provider. Geoffrey Porges, a stock analyst at the investment bank SVB lasix med Leerink, recently estimated that sales of Pfizer’s antiviral hypertension medications pill could reach $24 billion in 2022.The FDA’s advisory committee will convene on Tuesday to discuss Merck’s pill.

The agency is seeking guidance on a few questions. Should pregnant women ever receive this drug? lasix med. Could the use of this medicine result in the evolution of new, more worrisome variants of the hypertension lasix, which causes hypertension medications?.

And, of lasix med course, should the medicine be authorized, and for whom?. In a 68-page document independently analyzing the molnupiravir trial results, FDA experts delve into the data behind each of those questions.The FDA does not seem concerned about one of the main worries that has been raised about molnupiravir. That it could cause mutations in lasix med people, thereby leading to cancer or other long-term health problems.

A test done on bacteria, known as an Ames assay, did show a risk of mutation, called mutagenicity, the FDA says. But follow-up tests in a particular type of rat did not show a problem, and it is unlikely, the agency says, that such a problem would occur after just five days of treatment.“Given the negative in vivo assay results, and considering the 5-day treatment duration with MOV, the Agency pharmacology/toxicology experts have concluded the risk of mutagenicity in the clinic is low,” the FDA reviewers said.But the FDA did have a concern about whether or not molnupiravir should be given to so-called breakthrough cases, people who have been vaccinated against hypertension medications but still get infected. The agency points to a subgroup of patients in the study who had antibodies to lasix med hypertension medications who did not seem to benefit from molnupiravir.

That group, though, was far too small to draw conclusions.The FDA also had concerns about using molnupiravir in pregnant women and children. (Merck and the FDA agree that the drug should not be authorized for people under 18.) In studies in rats of a dose much higher than is given to people, researchers saw reductions lasix med in fetal body weight as well as “external, visceral, and skeletal malformations” in surviving fetuses.The FDA proposes two ways of handling the risk in pregnant women. One approach would simply state that no pregnant women should receive the drug.

A second lasix med would be to include warnings, but allow physicians to prescribe the medicine if they thought it was warranted. The FDA’s advisory committee will be asked to weigh in on which approach to take. The FDA does propose that women should take a pregnancy test before being prescribed the lasix med drug.Nowhere in its analysis does the FDA seem to contemplate not making molnupiravir available.

But adding restrictions will make the drug more difficult to give in practice, and could also make the Pfizer pill a preferred option, if data on that medicine hold up better than the data around molnupiravir have. This is a case where the opinions of the FDA’s expert panelists are likely to hold even more weight than usual.Merck shares dipped almost lasix med 4% in morning trading. Pfizer shares rose more than 5%.A common in vitro fertilization procedure offered to patients with the promise of increasing their likelihood of successful pregnancy actually does not improve healthy patients’ chances of going home with a baby, according to new research published in the New England Journal of Medicine this week.The study focuses on preimplantation genetic testing for aneuploidy, or PGT-A, which screens embryos for chromosomal abnormalities that could keep them from implanting.

The diagnostic tool has been controversial for decades, since no lasix med rigorous studies have conclusively proven the test improves the odds of having a baby. Studies as far back as 2007 showed an earlier, more invasive version of the test, called PGS, harmed patients’ chances of having a child. Nonetheless, PGT-A has been sold to prospective parents across the world, bolstering the multibillion-dollar lasix med industry of reproductive medicine.Clinicians and researchers told STAT say they believe most providers have good intentions, but they are still offering patients an unproven, expensive, and possibly risky procedure.advertisement “I do not suspect that clinics have been performing PGT-A for financial reasons in face of the realization of the questionable evidence supporting it,” said Hank Greely, chair of the steering committee for the Stanford Center for Biomedical Ethics.

€œInstead, the procedure has seemed that it should work, or perhaps even must work, and so help prospective parents realize their dreams. But expectations, and hopes, need to be weighed by evidence and, right now, the evidence for widespread PGT-A screening is, at best, weak.” The new research, a randomized controlled trial of 1,212 patients, found that PGT-A did not benefit women ages 20 to 37 with a good prognosis for live birth, when compared to conventional IVF.advertisement “This raises the possibility that some patients may have paid for this expensive treatment, and in doing so, may have reduced their chances of having a baby through IVF,” said Jack Wilkinson, a research fellow at the University of Manchester in the U.K. Who analyzes lasix med reproductive medicine data.

€œThe result is in line with other good-quality studies which have failed to find any benefit of PGT-A.”From July 2017 to June 2018, researchers at 14 academic fertility centers in China randomly split 1,212 patients into two groups. Regular IVF lasix med and PGT-A. All of the patients were women who already had a good prognosis for live birth and whose eggs, when fertilized in IVF, resulted in three or more healthy blastocysts, or five-day-old embryos.

Embryos that survive to the blastocyst stage stand a good chance of implantation lasix med once placed in the uterus. The researchers then followed patients for a year from when the women were assigned a group — tracking the success of up to three transferred embryos.Those using donor eggs or sperm, with known uterine abnormalities, or with conditions that could make for dangerous pregnancies, were excluded from the study. Patients who planned to use other, noncontroversial versions of PGT to screen for genetic diseases like cystic fibrosis, or parental lasix med chromosomal issues, were also left out.

All patients were entering their first IVF cycle, which is typically a month-long process that involves stimulating the ovaries, retrieving viable eggs, fertilizing them, growing an embryo in a lab and implanting the embryo. Related lasix med. IVF can be a painstaking process.

Could AI make it more lasix med precise?. Unlike other researchers who have studied PGT-A, the researchers in China who authored this multi-center study focused on what they call “the most important patient-centered outcome” — cumulative live birth rate — instead of success rate per embryo transfer, senior author Zi-Jiang Chen told STAT. In other words, the study asked lasix med.

For a patient with a good prognosis, “What’s the chance I’m gonna take home a baby?. € as Marcelle Cedars, president of the American Society for Reproductive Medicine, put it.In the study, 77% of women in the PGT-A group had a live birth, compared to 81.8% of women in the conventional IVF group.The data suggests, “in a good prognosis patient, you aren’t helping these people,” said Cedars, a professor of reproductive endocrinology and infertility at the University of California at San Francisco School of Medicine.Yet Chen, the senior author, said, “We cannot completely deny PGT-A.” More research is needed to know if the test could help certain patient populations, experts said. For example, the study lasix med results suggest that those who received PGT-A had slightly lower rates of miscarriage, and that PGT-A patients became pregnant with fewer embryo transfers.

Expanding the patient pool, including all available patient embryos in the study (instead of just three), and tracking outcomes from the very beginning of treatment, at the start of ovarian stimulation, would also paint a clearer picture, Cedars said.Both proponents and critics of PGT-A will say there is evidence that the transfer success rate is higher with PGT-A than in conventional IVF. Since the test is used to identify and discard flawed embryos, leaving a pool lasix med of only the “strongest” contenders, the success rate per embryo transferred into a patient will automatically go up. Related.

The staggering toll of complications related to pregnancy and childbirth However, the chances of successful pregnancy overall don’t increase, because “you don’t add any embryos, you don’t pick embryos out of thin air,” said Sebastiaan Mastenbroek, a lasix med clinical embryologist at the Center for Reproductive Medicine at the Amsterdam University Medical Centers, who set off a firestorm when he published one of the first studies showing PGS could harm a patient’s chances of getting pregnant.In simple terms. If a patient has six embryos, and two are discarded because a PGT-A screening found a problem, it’s the mathematical difference between dividing the number of successful pregnancies by the four remaining embryos, rather than the six at the start.Many papers that focus on the success rate per embryo transfer don’t account for the embryos that were thrown out but could have been viable, Cedars and Mastenbroek told STAT. Studies have shown that even young embryos with chromosomal abnormalities can lead to healthy live births, since the test may show false positives or negatives, and genetic quirks may be weeded out during fetal development, or abnormalities may only be present in certain cell lines, and not all of them.Those studies also don’t account for IVF treatments that were started but did not result in an embryo transfer or pregnancy because all embryos were labeled lasix med as aneuploid by PGT-A, therefore overestimating the success of PGT-A, Mastenbroek said.In the past 20 years, “viable, healthy embryos have been thrown away in the bin and, with that, you’ve lowered the pregnancy rates of hundreds of thousands of women,” he told STAT.

€œThat’s shocking.” Trending Now. What’s known and unknown about Omicron, the hypertension variant identified in South Africa The NEJM study, which was led by Junhao Yan of Shandong Provincial Clinical Research Center for Reproductive Health, is one of several that have shown no improvement in cumulative live birth rates when patients undergo lasix med PGT-A. But still, there remains a paucity of high-quality, large-scale, randomized controlled trials, according to Mastenbroek, who conducted a systematic review and meta-analysis of scientific literature on PGT-A for the Cochrane Collaboration.“If after 25 years, a field is not able to prove that something works, something is wrong, either with the technique, the information, or with the field,” he said.Supplementary procedures, such as PGT-A — which is listed alongside dozens of other add-ons at IVF clinics in the U.S.

And abroad — can be sold to lasix med patients even when there is little to no scientific evidence that they increase patients’ chances of having a child. Assisted reproduction is largely unregulated in the U.S. Because these procedures are not tested like drugs, IVF add-ons don’t need to be shown to benefit the lasix med patient before entering the market.

Many of the add-ons rest on flimsy science and big marketing budgets, targeting patients desperate for anything that will improve the odds of having a child.PGT-A is one of the most widely used add-ons, though it’s difficult to say exactly how often it is used because of incomplete data reporting. Some clinics use the test on a majority of patients, while others rarely do — a divide that illustrates the ongoing debate about the test. €œThat, in lasix med itself, is very strange,” said Mastenbroek, who wrote an opinion piece to accompany the study in NEJM.

He added that in conventional IVF, daily inspections of embryos under a microscope are effective at ranking embryos based on their implantation potential. So if PGT-A is shown to be bad at its primary lasix med task — accurately identifying non-viable embryos — its use would be extremely limited, possibly to the point of obsolescence, he said.It’s somewhat difficult to study PGT-A in the U.S., given restrictions on federal funding for certain types of research involving embryos, Cedars said. Research from other countries is helpful, but reproductive medicine also works differently — frequently, in private practices owned by large companies — within the confines of the American health care system.Much of reproductive medicine in the U.S.

Takes place in private clinics, so providers compete for lasix med patients. If a patient is insistent upon receiving PGT-A or another supplemental procedure, doctors might succumb to the pressure in lieu of losing a patient to someone else, said Mastenbroek, who does not offer PGT-A at his clinic.For patients, it can be disorienting trying to figure out what is best, especially when jargon-laden scientific literature exists both in support of PGT-A and against it. And the difference, sometimes, to the untrained eye, is the splitting lasix med of a hair in the data.A recent example.

Earlier this month, a study came out suggesting PGT-A offered some benefits over regular IVF. Wilkinson, the Manchester biostatistician, calls the paper “critically flawed,” and said it compared “lots of apples with lots of oranges.” The senior author of that study, Darren Griffin of the University of Kent in the U.K., said, “PGT-A is targeted to patients of advanced maternal age, recurrent implantation failure, recurrent miscarriage,” and therefore he didn’t expect it lasix med to work in the younger, healthier patients Yan studied.It’s a contradictory finding that only adds to the confusion among patients trying to muddle through the data. And the data on the treatment still doesn’t cut it, experts said.“When a treatment hasn’t been adequately tested, the worst case scenario isn’t that it has no effect.

It could actually make things worse,” lasix med said Wilkinson. €œThis point is usually ignored.”Many Americans are becoming accustomed to discussing how lasix-related lockdowns and remote engagement have changed our lives. The conversations tend to be mechanical and superficial, like discussing the weather, and often include references to changes in eating or jokes lasix med about “the lasix 15” to reflect weight gain from sitting too much or too close to the homemade bread.But for one segment of the population, lasix-related changes in eating habits are no joke.

As we and several colleagues reported in JAMA Network Open, data from a large national health insurer showed substantial increases in hospitalizations among people with anorexia nervosa, bulimia nervosa, and other eating disorders, such as binge-eating disorder, starting in the second half of 2020. Hospitalization rates for these conditions roughly doubled compared to the rates in the prior two years. And individuals admitted to the hospital tended to lasix med stay about 50% longer, suggesting the disorders were more severe.We saw no changes in outpatient visits or hospitalizations for other common mental health conditions like depression, alcohol use, or opioid use, suggesting that the lasix is having a particular effect on people susceptible to eating disorders.advertisement Although it isn’t entirely clear to us why this has happened, understanding some of the reasons can help families and clinicians recognize these problems earlier and provide appropriate services.

First, messaging about the link between obesity and the severity of hypertension medications and on connections between self-quarantine and weight gain have likely been hard on people susceptible to eating disorders. These messages may have prompted some to engage in restrictive lasix med eating behaviors, such as refusing to eat certain foods or labeling foods as “good” or “bad,” which can lead to more severe weight loss in those with anorexia and to more severe binge eating and compensatory behaviors, such as vomiting or laxative use, among those with bulimia.advertisement Second, especially in the beginning of the lasix, grocery shopping became a more complicated and difficult task due to fears of contracting hypertension medications in public places like grocery stores, the limited availability of some foods and household items, and strict rules and rituals for shoppers. Food shopping, an already anxiety-provoking task for individuals prone to eating disorders, became even more difficult.Third, during the lasix, many people bought large quantities of processed, pre-packaged comfort foods to minimize how often they needed to shop and out of concern for food shortages.

Being confined at home in close proximity to these foods likely led to increases in mindless eating and snacking for many lasix med people, as well as bingeing episodes for those prone to eating disorders, particularly since people had fewer distractions and distance from food.Fourth, exercise was one of the few activities promoted as safe and healthy during the lasix. For many individuals with eating disorders, exercise may have become a way to control an uncontrollable situation or a compensatory mechanism for eating. In one recent study, a majority of patients with lasix med anorexia who had participated in treatment in 2019 reported during the lasix that they had increased concerns about eating, body shape and weight.

A higher drive for physical activity. And more loneliness, sadness, and inner restlessness.Fifth, social anxiety, stress, and lasix med depressed mood often go hand-in-hand with eating disorders and all worsened during this time. Related.

Among people facing food insecurity, researchers find a lasix med hidden health issue. Eating disorders These five factors likely increased eating disorder symptoms. But a collection of other circumstances may have made eating disorders easier to discover and, perhaps, harder to treat.Stay-at-home orders, remote schooling, and the closure of college campuses may have helped families better identify unhealthy rapid weight loss or binge eating, or more clearly see its psychological burdens, leading family members to seek treatment for lasix med their loved ones.

At the same time, outpatient facilities struggling to adapt their operations during the lasix may not have had additional capacity to see these patients when their symptoms warranted a lower level of care, thus delaying treatment and intensifying the eating disorder. Similarly, fears of contracting hypertension medications may have influenced individuals and family members to delay seeking care until symptoms were severe enough to require inpatient care.Food is a large part of life. For those with lasix med eating disorders, food and its rituals are also great sources of anxiety.

Many people living with these disorders have struggled even more during the lasix. As it shifts and society adjusts to a new normal, it’s important to recognize the burden the lasix continues to impose on people with eating disorders. In a society where appearance is highly prized, eating disorders are often considered less important and more under the control of those who experience them than other mental health disorders.

The lasix highlights the need to understand the particular triggers for individuals with eating disorders, identify the symptoms, and provide appropriate and early treatment.David A. Asch is an internal medicine physician, a senior fellow of the Leonard Davis Institute of Health Economics at the University of Pennsylvania, and executive director of the Penn Medicine Center for Health Care Innovation. Kelly C.

Allison is a psychologist and professor in the Department of Psychiatry at the Perelman School of Medicine at the University of Pennsylvania and director of Penn’s Center for Weight and Eating Disorders.Agnieszka Czechowicz remembers what the Magenta Therapeutics website looked like before the biotech startup went public. She, as a scientific co-founder, was featured on the website along with other, more junior co-founders. Then, as the company prepared for its IPO in 2018, she said, “suddenly the founders on the website were older, Caucasian men, even though some of those individuals were not part of the founding of the company during the early stages.” Unlock this article by subscribing to STAT+ and enjoy your first 30 days free!.

GET STARTED Log In | Learn More What is it?. STAT+ is STAT's premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond.

What's included?. Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr..

New data, in addition to analyses by scientists at the Food and Drug Administration, may take Lasix 40mg price some of get lasix prescription the shine off Merck’s experimental hypertension medications pill, molnupiravir.On Friday, the drug maker released full results from its study of the pill, molnupiravir, showing it reduced the risk of hospitalization by 30%, down from a decrease of 50% seen in an earlier analysis. In the 1,433-patient study, fewer patients died when they received the treatment. There were nine deaths in the placebo group in get lasix prescription the final analysis, and one in the molnupiravir group.The data were released as the FDA published its own analysis of molnupiravir ahead of a meeting of advisers being convened by the agency to vote on whether the medicine’s benefits outweigh its risks.advertisement In that analysis, FDA researchers seemed to favor the authorization of molnupiravir but raised concerns that could mean people who are at lower risk from the disease would not be offered the pill. Alex Hogan/STAT The fate of molnupiravir — developed in partnership between Merck and Ridgeback Therapeutics — is important for both society’s battle against hypertension medications and Merck’s financial fortunes.

Experts say that an easy-to-give, oral get lasix prescription treatment that keeps people who contract the hypertension lasix from being hospitalized or dying would go a long way toward helping society return to normal. Existing pills, such as hydroxychloroquine or ivermectin, have failed to deliver convincing results. Monoclonal antibodies treatments, though very effective, must be given as shots or intravenous infusions.advertisement Pfizer recently released results on its own get lasix prescription hypertension medications pill, showing an 89% decrease in hospitalizations in an interim analysis.As governments buy large amounts of both pills, the financial stakes could be enormous. During its October earnings call, Merck said molnupiravir could generate between $500 million and $1 billion this year and between $5 billion and $7 billion next year, according to a transcript STAT obtained through Senteio, a financial database provider.

Geoffrey Porges, a stock analyst at get lasix prescription the investment bank SVB Leerink, recently estimated that sales of Pfizer’s antiviral hypertension medications pill could reach $24 billion in 2022.The FDA’s advisory committee will convene on Tuesday to discuss Merck’s pill. The agency is seeking guidance on a few questions. Should pregnant women ever receive this get lasix prescription drug?. Could the use of this medicine result in the evolution of new, more worrisome variants of the hypertension lasix, which causes hypertension medications?.

And, of course, should the medicine be get lasix prescription authorized, and for whom?. In a 68-page document independently analyzing the molnupiravir trial results, FDA experts delve into the data behind each of those questions.The FDA does not seem concerned about one of the main worries that has been raised about molnupiravir. That it get lasix prescription could cause mutations in people, thereby leading to cancer or other long-term health problems. A test done on bacteria, known as an Ames assay, did show a risk of mutation, called mutagenicity, the FDA says.

But follow-up tests in a particular type of rat did not show a problem, and it is unlikely, the agency says, that such a problem would occur after just five days of treatment.“Given the negative in vivo assay results, and considering the 5-day treatment duration with MOV, the Agency pharmacology/toxicology experts have concluded the risk of mutagenicity in the clinic is low,” the FDA reviewers said.But the FDA did have a concern about whether or not molnupiravir should be given to so-called breakthrough cases, people who have been vaccinated against hypertension medications but still get infected. The agency points to a subgroup of patients in the study who had antibodies to hypertension medications who did not seem to benefit from molnupiravir get lasix prescription. That group, though, was far too small to draw conclusions.The FDA also had concerns about using molnupiravir in pregnant women and children. (Merck and the FDA agree that the drug should not be authorized for people under 18.) In studies in rats of a dose much higher get lasix prescription than is given to people, researchers saw reductions in fetal body weight as well as “external, visceral, and skeletal malformations” in surviving fetuses.The FDA proposes two ways of handling the risk in pregnant women.

One approach would simply state that no pregnant women should receive the drug. A second would be to include warnings, but allow physicians to prescribe get lasix prescription the medicine if they thought it was warranted. The FDA’s advisory committee will be asked to weigh in on which approach to take. The FDA does propose that women should take get lasix prescription a pregnancy test before being prescribed the drug.Nowhere in its analysis does the FDA seem to contemplate not making molnupiravir available.

But adding restrictions will make the drug more difficult to give in practice, and could also make the Pfizer pill a preferred option, if data on that medicine hold up better than the data around molnupiravir have. This is a case where the opinions of the FDA’s expert panelists are likely to hold even more weight than usual.Merck shares get lasix prescription dipped almost 4% in morning trading. Pfizer shares rose more than 5%.A common in vitro fertilization procedure offered to patients with the promise of increasing their likelihood of successful pregnancy actually does not improve healthy patients’ chances of going home with a baby, according to new research published in the New England Journal of Medicine this week.The study focuses on preimplantation genetic testing for aneuploidy, or PGT-A, which screens embryos for chromosomal abnormalities that could keep them from implanting. The diagnostic tool has been controversial for decades, since no rigorous studies have conclusively proven the test get lasix prescription improves the odds of having a baby.

Studies as far back as 2007 showed an earlier, more invasive version of the test, called PGS, harmed patients’ chances of having a child. Nonetheless, PGT-A has been sold to prospective parents across the world, bolstering the multibillion-dollar industry of reproductive medicine.Clinicians and researchers told STAT say they believe most providers have good intentions, but they are still offering patients an unproven, expensive, and possibly risky procedure.advertisement “I do not suspect that clinics have been performing PGT-A for financial reasons in face of the realization of the get lasix prescription questionable evidence supporting it,” said Hank Greely, chair of the steering committee for the Stanford Center for Biomedical Ethics. €œInstead, the procedure has seemed that it should work, or perhaps even must work, and so help prospective parents realize their dreams. But expectations, and hopes, need to be weighed by evidence and, right now, the evidence for widespread PGT-A screening is, at best, weak.” The new research, a randomized controlled trial of 1,212 patients, found that PGT-A did not benefit women ages 20 to 37 with a good prognosis for live birth, when compared to conventional IVF.advertisement “This raises the possibility that some patients may have paid for this expensive treatment, and in doing so, may have reduced their chances of having a baby through IVF,” said Jack Wilkinson, a research fellow at the University of Manchester in the U.K.

Who analyzes reproductive get lasix prescription medicine data. €œThe result is in line with other good-quality studies which have failed to find any benefit of PGT-A.”From July 2017 to June 2018, researchers at 14 academic fertility centers in China randomly split 1,212 patients into two groups. Regular IVF and PGT-A get lasix prescription. All of the patients were women who already had a good prognosis for live birth and whose eggs, when fertilized in IVF, resulted in three or more healthy blastocysts, or five-day-old embryos.

Embryos that survive to the blastocyst stage stand a good chance of implantation once placed in get lasix prescription the uterus. The researchers then followed patients for a year from when the women were assigned a group — tracking the success of up to three transferred embryos.Those using donor eggs or sperm, with known uterine abnormalities, or with conditions that could make for dangerous pregnancies, were excluded from the study. Patients who planned to use other, noncontroversial versions of PGT to screen for genetic diseases like cystic fibrosis, or parental chromosomal issues, were also get lasix prescription left out. All patients were entering their first IVF cycle, which is typically a month-long process that involves stimulating the ovaries, retrieving viable eggs, fertilizing them, growing an embryo in a lab and implanting the embryo.

Related get lasix prescription. IVF can be a painstaking process. Could AI make get lasix prescription it more precise?. Unlike other researchers who have studied PGT-A, the researchers in China who authored this multi-center study focused on what they call “the most important patient-centered outcome” — cumulative live birth rate — instead of success rate per embryo transfer, senior author Zi-Jiang Chen told STAT.

In other words, the study asked get lasix prescription. For a patient with a good prognosis, “What’s the chance I’m gonna take home a baby?. € as Marcelle Cedars, president of the American Society for Reproductive Medicine, put it.In the study, 77% of women in the PGT-A group had a live birth, compared to 81.8% of women in the conventional IVF group.The data suggests, “in a good prognosis patient, you aren’t helping these people,” said Cedars, a professor of reproductive endocrinology and infertility at the University of California at San Francisco School of Medicine.Yet Chen, the senior author, said, “We cannot completely deny PGT-A.” More research is needed to know if the test could help certain patient populations, experts said. For example, the study results suggest that those who received PGT-A had slightly get lasix prescription lower rates of miscarriage, and that PGT-A patients became pregnant with fewer embryo transfers.

Expanding the patient pool, including all available patient embryos in the study (instead of just three), and tracking outcomes from the very beginning of treatment, at the start of ovarian stimulation, would also paint a clearer picture, Cedars said.Both proponents and critics of PGT-A will say there is evidence that the transfer success rate is higher with PGT-A than in conventional IVF. Since the test is used get lasix prescription to identify and discard flawed embryos, leaving a pool of only the “strongest” contenders, the success rate per embryo transferred into a patient will automatically go up. Related. The staggering toll of complications related to pregnancy and childbirth However, the chances of successful pregnancy overall don’t increase, because “you don’t add any embryos, you don’t pick embryos out of thin air,” said Sebastiaan Mastenbroek, a clinical embryologist get lasix prescription at the Center for Reproductive Medicine at the Amsterdam University Medical Centers, who set off a firestorm when he published one of the first studies showing PGS could harm a patient’s chances of getting pregnant.In simple terms.

If a patient has six embryos, and two are discarded because a PGT-A screening found a problem, it’s the mathematical difference between dividing the number of successful pregnancies by the four remaining embryos, rather than the six at the start.Many papers that focus on the success rate per embryo transfer don’t account for the embryos that were thrown out but could have been viable, Cedars and Mastenbroek told STAT. Studies have shown that even young embryos with chromosomal abnormalities can lead to healthy live births, since the test may show false positives or negatives, and genetic quirks may be weeded out during fetal development, or abnormalities may only be present in certain cell lines, and not all of them.Those studies also don’t account for IVF treatments that get lasix prescription were started but did not result in an embryo transfer or pregnancy because all embryos were labeled as aneuploid by PGT-A, therefore overestimating the success of PGT-A, Mastenbroek said.In the past 20 years, “viable, healthy embryos have been thrown away in the bin and, with that, you’ve lowered the pregnancy rates of hundreds of thousands of women,” he told STAT. €œThat’s shocking.” Trending Now. What’s known and unknown about Omicron, the hypertension variant identified in South Africa The NEJM study, which was led by Junhao Yan of Shandong Provincial Clinical Research Center for Reproductive Health, is one of several that have shown no improvement in cumulative live birth rates when get lasix prescription patients undergo PGT-A.

But still, there remains a paucity of high-quality, large-scale, randomized controlled trials, according to Mastenbroek, who conducted a systematic review and meta-analysis of scientific literature on PGT-A for the Cochrane Collaboration.“If after 25 years, a field is not able to prove that something works, something is wrong, either with the technique, the information, or with the field,” he said.Supplementary procedures, such as PGT-A — which is listed alongside dozens of other add-ons at IVF clinics in the U.S. And abroad — can be sold to patients even when there is little to no scientific evidence get lasix prescription that they increase patients’ chances of having a child. Assisted reproduction is largely unregulated in the U.S. Because these procedures are not tested like drugs, IVF add-ons don’t get lasix prescription need to be shown to benefit the patient before entering the market.

Many of the add-ons rest on flimsy science and big marketing budgets, targeting patients desperate for anything that will improve the odds of having a child.PGT-A is one of the most widely used add-ons, though it’s difficult to say exactly how often it is used because of incomplete data reporting. Some clinics use the test on a majority of patients, while others rarely do — a divide that illustrates the ongoing debate about the test. €œThat, in itself, is very strange,” said Mastenbroek, get lasix prescription who wrote an opinion piece to accompany the study in NEJM. He added that in conventional IVF, daily inspections of embryos under a microscope are effective at ranking embryos based on their implantation potential.

So if PGT-A get lasix prescription is shown to be bad at its primary task — accurately identifying non-viable embryos — its use would be extremely limited, possibly to the point of obsolescence, he said.It’s somewhat difficult to study PGT-A in the U.S., given restrictions on federal funding for certain types of research involving embryos, Cedars said. Research from other countries is helpful, but reproductive medicine also works differently — frequently, in private practices owned by large companies — within the confines of the American health care system.Much of reproductive medicine in the U.S. Takes place in private clinics, so providers compete for get lasix prescription patients. If a patient is insistent upon receiving PGT-A or another supplemental procedure, doctors might succumb to the pressure in lieu of losing a patient to someone else, said Mastenbroek, who does not offer PGT-A at his clinic.For patients, it can be disorienting trying to figure out what is best, especially when jargon-laden scientific literature exists both in support of PGT-A and against it.

And the difference, sometimes, to the untrained eye, is the splitting of a hair in the data.A recent example get lasix prescription. Earlier this month, a study came out suggesting PGT-A offered some benefits over regular IVF. Wilkinson, the Manchester biostatistician, calls the paper “critically flawed,” and said it compared “lots of apples with lots of oranges.” The senior author of that study, Darren Griffin of the University of Kent in the U.K., said, “PGT-A is targeted to patients of advanced maternal age, recurrent implantation failure, recurrent miscarriage,” and therefore he didn’t expect it to work in the younger, healthier patients Yan get lasix prescription studied.It’s a contradictory finding that only adds to the confusion among patients trying to muddle through the data. And the data on the treatment still doesn’t cut it, experts said.“When a treatment hasn’t been adequately tested, the worst case scenario isn’t that it has no effect.

It could actually make things get lasix prescription worse,” said Wilkinson. €œThis point is usually ignored.”Many Americans are becoming accustomed to discussing how lasix-related lockdowns and remote engagement have changed our lives. The conversations tend to be mechanical and superficial, like discussing the weather, and often get lasix prescription include references to changes in eating or jokes about “the lasix 15” to reflect weight gain from sitting too much or too close to the homemade bread.But for one segment of the population, lasix-related changes in eating habits are no joke. As we and several colleagues reported in JAMA Network Open, data from a large national health insurer showed substantial increases in hospitalizations among people with anorexia nervosa, bulimia nervosa, and other eating disorders, such as binge-eating disorder, starting in the second half of 2020.

Hospitalization rates for these conditions roughly doubled compared to the rates in the prior two years. And individuals admitted to the hospital tended to stay about 50% longer, suggesting the disorders were more severe.We saw no changes in outpatient visits or hospitalizations for other common mental health conditions like depression, alcohol use, or opioid use, suggesting that the lasix is having a particular effect on people susceptible to eating disorders.advertisement Although it isn’t entirely clear to us why this has happened, understanding some of the reasons can help families and get lasix prescription clinicians recognize these problems earlier and provide appropriate services. First, messaging about the link between obesity and the severity of hypertension medications and on connections between self-quarantine and weight gain have likely been hard on people susceptible to eating disorders. These messages may have prompted some to engage in restrictive eating behaviors, such as refusing to eat certain foods or labeling foods as “good” or “bad,” which can lead to more severe weight loss in those with anorexia and to more severe binge eating and compensatory behaviors, such as vomiting or laxative use, among those with bulimia.advertisement Second, especially in the beginning of the lasix, grocery shopping became a more complicated and difficult task due to fears of contracting hypertension medications in public places like grocery stores, the limited availability of some foods and household items, and strict rules and rituals for shoppers get lasix prescription.

Food shopping, an already anxiety-provoking task for individuals prone to eating disorders, became even more difficult.Third, during the lasix, many people bought large quantities of processed, pre-packaged comfort foods to minimize how often they needed to shop and out of concern for food shortages. Being confined get lasix prescription at home in close proximity to these foods likely led to increases in mindless eating and snacking for many people, as well as bingeing episodes for those prone to eating disorders, particularly since people had fewer distractions and distance from food.Fourth, exercise was one of the few activities promoted as safe and healthy during the lasix. For many individuals with eating disorders, exercise may have become a way to control an uncontrollable situation or a compensatory mechanism for eating. In one recent study, a majority of patients with anorexia who had participated in treatment in 2019 reported during get lasix prescription the lasix that they had increased concerns about eating, body shape and weight.

A higher drive for physical activity. And more loneliness, sadness, and inner restlessness.Fifth, get lasix prescription social anxiety, stress, and depressed mood often go hand-in-hand with eating disorders and all worsened during this time. Related. Among people facing food insecurity, researchers find a hidden health get lasix prescription issue.

Eating disorders These five factors likely increased eating disorder symptoms. But a collection of other circumstances may have made eating disorders easier to discover and, perhaps, harder to treat.Stay-at-home orders, get lasix prescription remote schooling, and the closure of college campuses may have helped families better identify unhealthy rapid weight loss or binge eating, or more clearly see its psychological burdens, leading family members to seek treatment for their loved ones. At the same time, outpatient facilities struggling to adapt their operations during the lasix may not have had additional capacity to see these patients when their symptoms warranted a lower level of care, thus delaying treatment and intensifying the eating disorder. Similarly, fears of contracting hypertension medications may have influenced individuals and family members to delay seeking care until symptoms were severe enough to require inpatient care.Food is a large part of life.

For those with eating disorders, food and its rituals are also great sources get lasix prescription of anxiety. Many people living with these disorders have struggled even more during the lasix. As it shifts and society adjusts to a new normal, it’s important to recognize the burden the lasix continues to impose get lasix prescription on people with eating disorders. In a society where appearance is highly prized, eating disorders are often considered less important and more under the control of those who experience them than other mental health disorders.

The lasix highlights the need get lasix prescription to understand the particular triggers for individuals with eating disorders, identify the symptoms, and provide appropriate and early treatment.David A. Asch is an internal medicine physician, a senior fellow of the Leonard Davis Institute of Health Economics at the University of Pennsylvania, and executive director of the Penn Medicine Center for Health Care Innovation. Kelly C get lasix prescription. Allison is a psychologist and professor in the Department of Psychiatry at the Perelman School of Medicine at the University of Pennsylvania and director of Penn’s Center for Weight and Eating Disorders.Agnieszka Czechowicz remembers what the Magenta Therapeutics website looked like before the biotech startup went public.

She, as a scientific co-founder, was featured on the website along with other, more junior co-founders. Then, as the company prepared for its IPO in 2018, she said, “suddenly the founders on the website were older, Caucasian men, even though some of those individuals were not part of the founding of the company during the early stages.” Unlock this article by subscribing to STAT+ and enjoy your first 30 days free!. GET STARTED Log In | Learn More What is it?. STAT+ is STAT's premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis.

Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. What's included?. Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr..

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How to Buy cialis online without prescription cite this article:Singh OP edema while taking lasix. Psychiatry research in India. Closing the edema while taking lasix research gap.

Indian J Psychiatry 2020;62:615-6Research is an important aspect of the growth and development of medical science. Research in India in general and medical research in particular is always being criticized for lack of innovation and originality required for the delivery of health services suitable to Indian conditions. Even the Indian Council of Medical Research (ICMR) which is a edema while taking lasix centrally funded frontier organization for conducting medical research couldn't avert criticism.

It has been criticized heavily for not producing quality research papers which are pioneering, ground breaking, or pragmatic solutions for health issues plaguing India. In the words of a leading daily, The ICMR could not even list one practical application of its hundreds of research papers published in various national and international research journals which helped cure any disease, or diagnose it with better accuracy or in less time, or even one new basic, applied or clinical research or innovation that opened a new frontier of scientific knowledge.[1]This clearly indicates that the health research output of ICMR is not up to the mark and is not commensurate with the magnitude of the disease burden in India. According to the 12th Plan Report, the country contributes to a fifth of the edema while taking lasix world's share of diseases.

The research conducted elsewhere may not be generalized to the Indian population owing to differences in biology, health-care systems, health practices, culture, and socioeconomic standards. Questions which are pertinent and specific to the Indian context may not be answered and will remain understudied. One of the vital elements in improving this situation is the need for relevant research base that would equip policymakers to take informed health policy decisions.The Parliamentary Standing Committee on Health and Family Welfare in the 100th report on Demand for Grants (2017–2018) of the Department of edema while taking lasix Health Research observed that “the biomedical research output needs to be augmented substantially to cater to the health challenges faced by the country.”[1]Among the various reasons, lack of fund, infrastructure, and resources is the prime cause which is glaringly evident from the inadequate budget allocation for biomedical research.

While ICMR has a budget of 232 million dollars per year on health research, it is zilch in comparison to the annual budget expenditure of the National Institute of Health, USA, on biomedical research which is 32 billion dollars.The lacuna of quality research is not merely due to lack of funds. There are other important issues which need to be considered and sorted out to end the status quo. Some of the factors which need our immediate attention are:Lack of research training and teachingImproper allocation of research facilitiesLack of information about research work happening globallyLack of promotion, motivation, commitment, and passion in the field of researchClinicians being overburdened with patientsLack of collaboration between medical colleges and established research institutesLack of continuity of research in successive batches of postgraduate (PG) students, leading to wastage of edema while taking lasix previous research and resourcesDifficulty in the application of basic biomedical research into pragmatic intervention solutions due to lack of interdisciplinary technological support/collaboration between basic scientists, clinicians, and technological experts.Majority of the biomedical research in India are conducted in medical institutions.

The majority of these are done as thesis submission for fulfillment of the requirement of PG degree. From 2015 onward, publication of papers had been made an obligatory requirement for promotion of faculty to higher posts. Although it offered a unique opportunity for training edema while taking lasix of residents and stimulus for research, it failed to translate into production of quality research work as thesis was limited by time and it had to be done with other clinical and academic duties.While the top four medical colleges, namely AIIMS, New Delhi.

PGIMER, Chandigarh. CMC, Vellore edema while taking lasix. And SGIMS, Lucknow are among the top ten medical institutions in terms of publication in peer-reviewed journals, around 332 (57.3%) medical colleges have no research paper published in a decade between 2004 and 2014.[2]The research in psychiatry is realistically dominated by major research institutes which are doing commendable work, but there is a substantial lack of contemporary research originating from other centers.

Dr. Chittaranjan Andrade (NIMHANS, edema while taking lasix Bengaluru) and Dr. K Jacob (CMC, Vellore) recently figured in the list of top 2% psychiatry researchers in the world from India in psychiatry.[3] Most of the research conducted in the field of psychiatry are limited to caregivers' burden, pathways of care, and other topics which can be done in limited resources available to psychiatry departments.

While all these areas of work are important in providing proper care and treatment, there is overabundance of research in these areas.The Government of India is aggressively looking forward to enhancing the quality of research and is embarking on an ambitious project of purchasing all major journals and providing free access to universities across the country. The India Genome Project started in January, 2020, edema while taking lasix is a good example of collaboration. While all these actions are laudable, a lot more needs to be done.

Following are some measures which will reduce the gap:Research proposals at the level of protocol can be guided and mentored by institutes. Academic committees of different zones and journals can help in this endeavorBreaking the cubicles by establishing a collaboration between medical colleges and various edema while taking lasix institutes. While there is a lack of resources available in individual departments, there are universities and institutes with excellent infrastructure.

They are not aware of the requirements of the field of psychiatry and research questions. Creation of an alliance will enhance the quality edema while taking lasix of research work. Some of such institutes include Centre for Neuroscience, Indian Institute of Science, Bengaluru.

CSIR-Institute of edema while taking lasix Genomics and Integrative Biology, New Delhi. And National Institute of Biomedical Genomics, KalyaniInitiation and establishment of interactive and stable relationships between basic scientists and clinical and technological experts will enhance the quality of research work and will lead to translation of basic biomedical research into real-time applications. For example, work on artificial intelligence for mental health.

Development of edema while taking lasix Apps by IITs. Genome India Project by the Government of India, genomic institutes, and social science and economic institutes working in the field of various aspects of mental healthUtilization of underutilized, well-equipped biotechnological labs of nonmedical colleges for furthering biomedical researchMedical colleges should collaborate with various universities which have labs providing testing facilities such as spectroscopy, fluoroscopy, gamma camera, scintigraphy, positron emission tomography, single photon emission computed tomography, and photoacoustic imagingCreating an interactive, interdepartmental, intradepartmental, and interinstitutional partnershipBy developing a healthy and ethical partnership with industries for research and development of new drugs and interventions.Walking the talk – the psychiatric fraternity needs to be proactive and rather than lamenting about the lack of resource, we should rise to the occasion and come out with innovative and original research proposals. With the implementation of collaborative approach, we can not only enhance and improve the quality of our research but to an extent also mitigate the effects of resource crunch and come up as a leader in the field of biomedical research.

References 1.2.Nagoba B, Davane edema while taking lasix M. Current status of medical research in India. Where are we?.

Walawalkar Int edema while taking lasix Med J 2017;4:66-71. 3.Ioannidis JP, Boyack KW, Baas J. Updated science-wide author databases of standardized citation indicators.

PLoS Biol edema while taking lasix 2020;18:e3000918. Correspondence Address:Dr. Om Prakash SinghAA 304, Ashabari Apartments, O/31, Baishnabghata, Patuli Township, Kolkata - 700 094, West Bengal IndiaSource of Support.

None, Conflict of Interest edema while taking lasix. NoneDOI. 10.4103/indianjpsychiatry.indianjpsychiatry_1362_2.

How to cite this http://bryant-heating.com/buy-cialis-online-without-prescription/ article:Singh get lasix prescription OP. Psychiatry research in India. Closing the research get lasix prescription gap. Indian J Psychiatry 2020;62:615-6Research is an important aspect of the growth and development of medical science. Research in India in general and medical research in particular is always being criticized for lack of innovation and originality required for the delivery of health services suitable to Indian conditions.

Even the Indian get lasix prescription Council of Medical Research (ICMR) which is a centrally funded frontier organization for conducting medical research couldn't avert criticism. It has been criticized heavily for not producing quality research papers which are pioneering, ground breaking, or pragmatic solutions for health issues plaguing India. In the words of a leading daily, The ICMR could not even list one practical application of its hundreds of research papers published in various national and international research journals which helped cure any disease, or diagnose it with better accuracy or in less time, or even one new basic, applied or clinical research or innovation that opened a new frontier of scientific knowledge.[1]This clearly indicates that the health research output of ICMR is not up to the mark and is not commensurate with the magnitude of the disease burden in India. According to the get lasix prescription 12th Plan Report, the country contributes to a fifth of the world's share of diseases. The research conducted elsewhere may not be generalized to the Indian population owing to differences in biology, health-care systems, health practices, culture, and socioeconomic standards.

Questions which are pertinent and specific to the Indian context may not be answered and will remain understudied. One of the vital elements in improving this situation is the need for relevant research base that would equip policymakers to take informed health policy decisions.The Parliamentary Standing Committee on Health and Family Welfare in the 100th report on Demand for Grants (2017–2018) of the Department of Health get lasix prescription Research observed that “the biomedical research output needs to be augmented substantially to cater to the health challenges faced by the country.”[1]Among the various reasons, lack of fund, infrastructure, and resources is the prime cause which is glaringly evident from the inadequate budget allocation for biomedical research. While ICMR has a budget of 232 million dollars per year on health research, it is zilch in comparison to the annual budget expenditure of the National Institute of Health, USA, on biomedical research which is 32 billion dollars.The lacuna of quality research is not merely due to lack of funds. There are other important issues which need to be considered and sorted out to end the status quo. Some of the factors which need our immediate attention are:Lack of research training and teachingImproper allocation of research facilitiesLack of information about research work happening globallyLack of promotion, motivation, commitment, and passion in the field of researchClinicians being overburdened with get lasix prescription patientsLack of collaboration between medical colleges and established research institutesLack of continuity of research in successive batches of postgraduate (PG) students, leading to wastage of previous research and resourcesDifficulty in the application of basic biomedical research into pragmatic intervention solutions due to lack of interdisciplinary technological support/collaboration between basic scientists, clinicians, and technological experts.Majority of the biomedical research in India are conducted in medical institutions.

The majority of these are done as thesis submission for fulfillment of the requirement of PG degree. From 2015 onward, publication of papers had been made an obligatory requirement for promotion of faculty to higher posts. Although it offered a unique opportunity for training of residents and stimulus for research, it failed to translate into production get lasix prescription of quality research work as thesis was limited by time and it had to be done with other clinical and academic duties.While the top four medical colleges, namely AIIMS, New Delhi. PGIMER, Chandigarh. CMC, Vellore get lasix prescription.

And SGIMS, Lucknow are among the top ten medical institutions in terms of publication in peer-reviewed journals, around 332 (57.3%) medical colleges have no research paper published in a decade between 2004 and 2014.[2]The research in psychiatry is realistically dominated by major research institutes which are doing commendable work, but there is a substantial lack of contemporary research originating from other centers. Dr. Chittaranjan Andrade get lasix prescription (NIMHANS, Bengaluru) and Dr. K Jacob (CMC, Vellore) recently figured in the list of top 2% psychiatry researchers in the world from India in psychiatry.[3] Most of the research conducted in the field of psychiatry are limited to caregivers' burden, pathways of care, and other topics which can be done in limited resources available to psychiatry departments. While all these areas of work are important in providing proper care and treatment, there is overabundance of research in these areas.The Government of India is aggressively looking forward to enhancing the quality of research and is embarking on an ambitious project of purchasing all major journals and providing free access to universities across the country.

The India Genome get lasix prescription Project started in January, 2020, is a good example of collaboration. While all these actions are laudable, a lot more needs to be done. Following are some measures which will reduce the gap:Research proposals at the level of protocol can be guided and mentored by institutes. Academic committees of different zones and journals can help in this endeavorBreaking the cubicles by establishing a collaboration get lasix prescription between medical colleges and various institutes. While there is a lack of resources available in individual departments, there are universities and institutes with excellent infrastructure.

They are not aware of the requirements of the field of psychiatry and research questions. Creation of an get lasix prescription alliance will enhance the quality of research work. Some of such institutes include Centre for Neuroscience, Indian Institute of Science, Bengaluru. CSIR-Institute of Genomics and Integrative get lasix prescription Biology, New Delhi. And National Institute of Biomedical Genomics, KalyaniInitiation and establishment of interactive and stable relationships between basic scientists and clinical and technological experts will enhance the quality of research work and will lead to translation of basic biomedical research into real-time applications.

For example, work on artificial intelligence for mental health. Development of get lasix prescription Apps by IITs. Genome India Project by the Government of India, genomic institutes, and social science and economic institutes working in the field of various aspects of mental healthUtilization of underutilized, well-equipped biotechnological labs of nonmedical colleges for furthering biomedical researchMedical colleges should collaborate with various universities which have labs providing testing facilities such as spectroscopy, fluoroscopy, gamma camera, scintigraphy, positron emission tomography, single photon emission computed tomography, and photoacoustic imagingCreating an interactive, interdepartmental, intradepartmental, and interinstitutional partnershipBy developing a healthy and ethical partnership with industries for research and development of new drugs and interventions.Walking the talk – the psychiatric fraternity needs to be proactive and rather than lamenting about the lack of resource, we should rise to the occasion and come out with innovative and original research proposals. With the implementation of collaborative approach, we can not only enhance and improve the quality of our research but to an extent also mitigate the effects of resource crunch and come up as a leader in the field of biomedical research. References 1.2.Nagoba B, Davane get lasix prescription M.

Current status of medical research in India. Where are we?. Walawalkar get lasix prescription Int Med J 2017;4:66-71. 3.Ioannidis JP, Boyack KW, Baas J. Updated science-wide author databases of standardized citation indicators.

PLoS Biol 2020;18:e3000918. Correspondence Address:Dr. Om Prakash SinghAA 304, Ashabari Apartments, O/31, Baishnabghata, Patuli Township, Kolkata - 700 094, West Bengal IndiaSource of Support. None, Conflict of Interest. NoneDOI.

10.4103/indianjpsychiatry.indianjpsychiatry_1362_2.