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To Thursday 30 December buy lasix water pills 2021 across NSW, 95 per cent of people aged 16 and over have received a first dose of a hypertension medications treatment, and 93.6 per cent have received two doses. Of the people aged 12 to 15, 81.5 per cent have received buy lasix water pills a first dose of hypertension medications treatment, and 78.2 per cent have received two doses.The total number of treatments administered in NSW is now 13,687,794, with 4,374,152 administered by NSW Health to 8pm last night and 9,313,642 administered by the GP network, pharmacies and other providers to 11.59pm on Thursday 30 December 2021.NSW Health encourages everyone who is eligible to book into a NSW Health vaccination clinic or another provider without delay through the hypertension medications treatment clinic finder.Booster doses of hypertension medications treatment are now available for people aged 18 and over. We urge people to get their booster dose as soon as they are eligible, to best protect themselves, their loved ones and the community from the ongoing transmission of hypertension medications. We also strongly recommend that people aged buy lasix water pills 12 years and over who are severely immunocompromised have a third primary dose of treatment from two months after their second dose. Sadly, NSW Health buy lasix water pills is today reporting the deaths of four people.

Three women and one man.One person was in their 60s, one person was in their 70s, and two people were in their 80s. One person was from inner Sydney, one was from south-eastern Sydney, one was from western Sydney, and one was from south-western Sydney.One person was unvaccinated, one person had received one dose of a hypertension medications treatment, and two people had received two doses of a hypertension medications treatment.One woman in her 80s was a resident of the Lilian Wells buy lasix water pills Nursing Home in North Parramatta, where she acquired her . It is the second death linked to an outbreak buy lasix water pills at this facility. NSW Health expresses its sincere condolences to their loved ones.There are currently 901 hypertension medications cases admitted to hospital, with 79 people in intensive care, 26 of whom require ventilation. There were 119,278 hypertension medications tests reported to 8pm last night, compared with the previous day's total of 148,410.NSW recorded 22,577 new cases of hypertension medications in the 24 hours to 8pm last night.Thirty hypertension medications cases have been excluded following further investigation, bringing the total number of cases in NSW since the beginning of the lasix to 209,862.Confirmed cases (including interstate residents in NSW health care facilities) 209,862Deaths (in NSW from confirmed cases)670Total tests carried out25,288,972Total vaccinations administered in NSW13,687,794Testing capacity in NSW is currently under enormous pressure and the only people getting a PCR (nose and throat swab) should be buy lasix water pills those who have hypertension medications symptoms.

Live in a household with a confirmed hypertension medications-positive buy lasix water pills case. Or have otherwise been advised by NSW Health to get tested. Interstate travellers and international arrivals are not required buy lasix water pills to have a PCR test and should instead undertake Rapid Antigen Tests, as per the guidelines for the respective states and territories.Symptomatic arrivals will be required to get a PCR as soon as possible and isolate until a negative result is received. If the PCR test is positive, the arrival must treat themselves as a positive case. This applies to people who are fully or partially vaccinated, as well as those not vaccinated.Rapid antigen testing can be an additional precaution that you can take buy lasix water pills if you are planning to socialise with large groups of people, particularly indoors, or interacting with people who are elderly or have serious health conditions.

Information on how to use rapid antigen tests is available on the NSW Government website.Around a quarter of people exposed to hypertension medications may still develop their beyond the buy lasix water pills 7 days after exposure. For the subsequent seven-day period, they should exercise caution and avoid high-risk settings and large indoor gatherings. Of the 22,577 cases reported to 8pm last night, 4,297 are from South Eastern Sydney Local Health District (LHD), 3,920 are from South Western Sydney LHD, 3,670 are from Western Sydney LHD, 2,613 are from Sydney LHD, 2,238 are from Northern Sydney LHD, 1,811 are from Hunter New England LHD, 1,023 are from Nepean Blue Mountains LHD, 809 are from Illawarra Shoalhaven LHD, 715 are from Central Coast LHD, 306 are from Northern NSW LHD, 203 are from Southern NSW LHD, 195 are from Mid North Coast LHD, 154 are from Murrumbidgee LHD, 152 are from Western NSW LHD, 16 are from Far West LHD, and 451 are yet buy lasix water pills to be assigned to an LHD. If you are directed to get tested for hypertension medications‑19 or self-isolate at any time, you must follow the self-isolation rules buy lasix water pills. If you have any hypertension medications symptoms, no matter how mild, get tested immediately and self-isolate until you receive a negative test result.

There are more than 450 buy lasix water pills hypertension medications testing locations across NSW, many of which are open seven days a week. To find your nearest clinic visit hypertension medications clinics or contact your GP.hypertension medications vaccination update All providers – first doses95%81.5% All providers – second doses 93.6%78.2% * to 11.59pm 30 December 2021NSW Health – first doses3942,207,393NSW Health – second doses 2131,935,935NSW Health – buy lasix water pills third doses4,749230,824* notified from 8pm 30 December 2021 to 8pm 31 December 2021 Today's video update​To ensure continued delivery of essential health services, asymptomatic healthcare workers in NSW's public and private facilities who are classified as close contacts will in exceptional circumstances be permitted to leave self-isolation so these key services are not disrupted.If these workers develop any symptoms of hypertension medications they must immediately seek a PCR test and not attend the workplace until a negative result is received. With increasing case numbers and large numbers of close contacts in self-isolation, NSW Health Minister Brad Hazzard today signed an exemption to the Public Health Order to minimise potential impacts on health services across the state.The exemption allows these close contacts to leave self-isolation to attend their workplace, provided they have been identified by their employer as critical to the service and cannot work from home.Under the exemption, healthcare workers must travel directly to and from their residence to their workplace. They are required to wear a mask at all times in their workplace, unless eating or drinking or providing services where it needs to be removed. These workers are also required to comply with risk-management strategies put in place by their employer..

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WASHINGTON – visit here The can lasix cause pancreatitis U.S. Department of Labor’s Employee Benefits Security Administration today released Field Assistance Bulletin 2021-03 announcing a temporary enforcement policy regarding the new fee transparency disclosure requirements added to the Employee Retirement Income Security Act for persons providing brokerage services and consulting to ERISA group health plans.The Consolidated Appropriations Act, 2021 included amendments of prohibited transaction exemption provisions in ERISA section 408(b)(2) that govern service provider arrangements with ERISA plans. The amendments require persons providing “brokerage can lasix cause pancreatitis services” or “consulting” to ERISA-covered group health plans to disclose detailed information to plan fiduciaries about the compensation that providers expect to be paid in connection with their services to the plan. Similar disclosure requirements already apply to pension plan service providers, and became effective in 2012 in the form of regulations issued by the department.

Both the pension and group health plan disclosure provisions specifically focus on helping plan fiduciaries guard against conflicts of interest that may arise when plan service providers receive compensation from third-parties, so-called indirect compensation, by ensuring that plan fiduciaries receive complete and timely information about such can lasix cause pancreatitis compensation before they enter into, renew or extend service provider arrangements. €œThe new disclosure requirements will help group health plans and their fiduciaries by shedding needed light on some of the complex and often opaque fee-sharing arrangements that unfortunately typify aspects of our healthcare system,” said Acting Assistant Secretary of Labor for Employee Benefits Security Ali Khawar. “The Field Assistance Bulletin can lasix cause pancreatitis gives plans and their brokerage and consulting service providers some transitional flexibility as they build systems to implement the new disclosure requirements, but that flexibility depends on reasonable and good faith behavior.” The disclosure requirements for group health plans applied beginning on December 27, 2021. The department understands that covered brokerage and consulting service providers have been working since the enactment of the new requirements to evaluate their existing disclosures and implement changes needed to make the required disclosure regarding their services and compensation in a way that complies with ERISA section 408(b)(2)(B).

During that time a number of stakeholders approached the department with questions can lasix cause pancreatitis about the scope and execution of the new disclosure requirements. FAB 2021-03 is intended to support the efforts of service providers who have been working diligently to comply with the new statutory requirements by providing stakeholders with an assurance that the department will be focused on helping service providers comply with the new requirements, and will focus its enforcement activities on cases in which covered service providers do not act in accordance with a good faith, reasonable interpretation of the statute. The FAB also contains a set of questions and answers that, pending further guidance, are designed to explain the department’s view about what constitutes a good faith, reasonable interpretation of the statute with respect to several key issues that had been raised by stakeholders..

WASHINGTON – The U.S buy lasix water pills. Department of Labor’s Employee Benefits Security Administration today released Field Assistance Bulletin 2021-03 announcing a temporary enforcement policy regarding the new fee transparency disclosure requirements added to the Employee Retirement Income Security Act for persons providing brokerage services and consulting to ERISA group health plans.The Consolidated Appropriations Act, 2021 included amendments of prohibited transaction exemption provisions in ERISA section 408(b)(2) that govern service provider arrangements with ERISA plans. The amendments require persons providing “brokerage services” or “consulting” to ERISA-covered group health plans to disclose detailed information to plan fiduciaries about the compensation that buy lasix water pills providers expect to be paid in connection with their services to the plan.

Similar disclosure requirements already apply to pension plan service providers, and became effective in 2012 in the form of regulations issued by the department. Both the pension and group health plan disclosure provisions specifically focus on helping plan fiduciaries guard against conflicts of interest that may arise when plan service providers receive compensation from third-parties, so-called indirect compensation, by ensuring that plan fiduciaries receive buy lasix water pills complete and timely information about such compensation before they enter into, renew or extend service provider arrangements. €œThe new disclosure requirements will help group health plans and their fiduciaries by shedding needed light on some of the complex and often opaque fee-sharing arrangements that unfortunately typify aspects of our healthcare system,” said Acting Assistant Secretary of Labor for Employee Benefits Security Ali Khawar.

“The Field Assistance Bulletin gives buy lasix water pills plans and their brokerage and consulting service providers some transitional flexibility as they build systems to implement the new disclosure requirements, but that flexibility depends on reasonable and good faith behavior.” The disclosure requirements for group health plans applied beginning on December 27, 2021. The department understands that covered brokerage and consulting service providers have been working since the enactment of the new requirements to evaluate their existing disclosures and implement changes needed to make the required disclosure regarding their services and compensation in a way that complies with ERISA section 408(b)(2)(B). During that time a number of stakeholders approached the department buy lasix water pills with questions about the scope and execution of the new disclosure requirements.

FAB 2021-03 is intended to support the efforts of service providers who have been working diligently to comply with the new statutory requirements by providing stakeholders with an assurance that the department will be focused on helping service providers comply with the new requirements, and will focus its enforcement activities on cases in which covered service providers do not act in accordance with a good faith, reasonable interpretation of the statute. The FAB also contains a set of questions and answers that, pending further guidance, are designed to explain the department’s view about what constitutes a good faith, reasonable interpretation of the statute with respect to several key issues that had been raised by stakeholders..

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Side effects that you should report to your doctor or health care professional as soon as possible:

• blood in urine or stools
• dry mouth
• fever or chills
• hearing loss or ringing in the ears
• irregular heartbeat
• muscle pain or weakness, cramps
• skin rash
• stomach upset, pain, or nausea
• tingling or numbness in the hands or feet
• unusually weak or tired
• vomiting or diarrhea
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• headache
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• unusual bleeding or bruising

This list may not describe all possible side effects.

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Dec. 30, 2021 – By 2025, 10 to 20 new cell and gene therapies will likely be approved each year, according to the FDA.Great news, right?. These products could save countless lives of people living with rare genetic diseases, like Sickle Cell, Progeria, and Spina Bifida.The hefty price tag for these treatments, however, could hinder cause for celebration, according to biotechnology and policy expert Kevin Doxzen, PhD, a Hoffmann Fellow at both Arizona State University, Tempe, and the World Economic Forum.In an article published in The Conversation, he cautions that gene therapies can cost hundreds of thousands to millions of dollars.A sickle cell treatment, which is expected to be approved in the next few years, could cost a single patient around $1.85 million dollars.

A Medicare program could pay around $30 million dollars each year, even if only 7% of those eligible get treated.Another example is Zolgensma, a one-time medication to treat spinal muscular atrophy, which is a disease that can cause your muscles to grow weak and decay, often leading to difficulty sitting up, walking, breathing, and swallowing. With a $2.1-million-dollar price tag, Zolgensma is the world’s most expensive drug.Raising large amounts of money for drugs like Zolgensma can be extremely taxing for those living with rare diseases and their families.Take Ayah Lundt, a young girl in Denmark highlighted in The Conversation article who was diagnosed with spinal muscular atrophy at 10 months old. After a grueling 7 ½ months of online fundraisers and auctions from large donors around the world, her family garnered enough support to raise the $2.1 million dollars to purchase Zolgensma.For some families, however, that approach may not be as successful.So how do these life-changing drugs get in the hands of patients in need?.

Creating payment models that help patients with the cost of treatment, while also keeping insurance programs and drug companies afloat, is one way, says Doxzen.In what is called “outcome-based models,” insurance could pay drug companies an initial fee, and then continue payments based on the patient’s progress after receiving treatment-- especially since costly drugs like Zolgensma aren’t guaranteed to be effective. The “Netflix model,” is another potential solution, Doxzen says.Operating like a subscription service, a state Medicaid program could pay drug companies a flat fee for unlimited access to gene therapies. This model helped create more access to hepatitis-C treatments for patients in Louisiana.Keto isn't new The Keto diet is another trendy weight-loss plan, although Susie warns that it's not all that new a concept.

"This diet has been around for a while," previously going by the names of Atkins or South Beach diets, Susie said. "I feel like it has a really great marketing manager, because every so often this diet gets rebranded." The Keto diet heavily restricts your intake of carbohydrates, while increasing your intake of fats and proteins. The goal is to reach a state of ketosis, "a metabolic state where you're burning fat for energy instead of burning carbohydrates for energy," Susie said.

"Basically you're asking your body to work off of fats instead of primarily carbohydrates in the diet," Cheskin said. However, the Keto diet can be tough on a person. "To get there can be a little bit brutal," Susie said, noting that people new to the diet often suffer a few days of the "Keto flu" during which they feel foggy-headed, lethargic and headachy.

Other common side effects are disrupted sleep and constipation. "When we remove some of these foods, we're taking away key nutrients and removing a lot of fiber," which can lead to constipation, Susie said. Keto's emphasis on fats also isn't very good for your heart, Cheskin added.

"In some ways, this is a heart attack diet," he said. "Eat all the bacon you want, just don't have potatoes -- well, you're eating a diet that's the opposite of what preventive cardiology would tell you to do." Folks will lose weight on Keto if they're eating less, "but you would probably obtain greater health benefit if you lose a similar amount of weight using a diet that is more healthful," Cheskin said. Beware Whole 30 Cheskin and Susie were the most critical of the Whole 30 Program, a diet in which participants cut out added sugars, grains, legumes and dairy for a solid month.

"What's a little concerning about the Whole 30 diet is this was founded by people that have limited nutrition education," Susie said. "It's extremely restrictive. For 30 days you are going to eliminate a lot of different food groups."Dec.

29, 2021 The U.S. Centers for Disease Control and Protection is investigating two separate listeria outbreaks linked to packaged salads produced by Fresh Express and Dole, the agency said in a food safety alert. Consumers who have the products at home should throw them out, and businesses should not sell them, the CDC says.

The Fresh Express recall was initiated Dec. 20 and covers salads with product codes Z324 through Z350 for all use-by dates Recalled brands include Fresh Express, Bowl &. Basket, Giant Eagle, Little Salad Bar, Marketside, O Organics, Signature Farms, Simply Nature, Weis Fresh from the Field, and Wellsley Farms Organic, the CDC said.

The U.S. Food and Drug Administration website has a full list of recalled Fresh Express products provided by the company. Routine product sampling in Michigan detected listeria in a 9-ounce bag of Fresh Express Sweet Hearts Romaine Lettuce Sweet Butter Lettuce, the Michigan Department of Agriculture and Rural Development said in a news release.

Dole Fresh Vegetables Inc. Started its recall Dec. 22 for Dole-branded and private label packaged salads processed at plants in Bessemer City, N.C., and Yuma, AZ., the company said in a news release also posted on the U.S.

Food and Drug Administration website. The recalled products have lot codes beginning with the letter “N” or “Y” in the upper right-hand corner of the package and have used-by dates between Nov. 30, 2021, and Jan.

8, 2022. Some of the products are sold under the Dole, Kroger, Little Salad Bar, Marketside, Naturally Better, Nature’s Promise, and Simply Nature labels. The FDA website has a full list of recalled Dole products.

Random sampling in Georgia and Michigan detected listeria in a Dole-branded Garden Salad from Bessemer City and a package of shredded iceberg lettuce from Yuma. The Bessemer City and Yuma facilities are temporarily closed for extensive cleaning, Dole said in the news release. No products from Dole plants in Springfield, OH., or Soledad, CA., are being recalled.

Springfield products have production lot codes beginning with “W” and Soledad products have a “B” production code. Listeria is a bacteria that can be found in dust, soil, animal feces, and other substances. If you eat something carrying the bacteria, it could lead to listeria , one of the main causes of food poisoning.

Symptoms of listeria can include nausea, diarrhea, and vomiting. Listeria usually doesn’t lead to serious illness if you’re healthy, though you may feel sick for a day or two. The can be particularly severe for the elderly and those with weakened immune systems, and possibly life-threatening for pregnant women and their babies.Dec.

29, 2021 -- We know a healthy lifestyle can help prevent health issues -- including cancer, heart disease, and type 2 diabetes -- but new research shows it may also lower the risk for heart disease and diabetes in people who already have had cancer.In a large study published in JACC. CardioOncology, researchers found that healthy living significantly reduced the risk of cancer, cardiovascular disease, and type 2 diabetes in a healthy population, and also lowered the risk of heart disease and type 2 diabetes (T2D) in those with a history of cancer."These findings highlight the benefits of adopting a combination of healthy behavioral practices in reducing the risk for CVD [heart disease] and T2D complications among patients with and without prevalent cancer," said the researchers, led by Zhi Cao of Tianjin Medical University’s School of Public Health in Tiagnjin, China.Healthy living was defined by five things. Not smoking, meeting guidelines for physical activity, following a healthy diet, moderate alcohol use, and moderate sleep duration.

That said, the connection to alcohol consumption as part of a healthy lifestyle should be taken with caution, says Erin D. Michos, MD, an associate professor of medicine and epidemiology and associate director of preventive cardiology at Johns Hopkins School of Medicine in Baltimore, who also co-authored an editorial published with the study.Alcohol -- even moderate use -- is a risk factor for many cancers, as well as for atrial fibrillation, or an irregular heart rhythm, she says."Its use is not endorsed as a preventive strategy by the American Heart Association or the American Society of Clinical Oncology."The researchers examined the impact of healthy living on 432,000 people ages 40 to 70 years who were enrolled in the UK BioBank, a database of genetic and health information from half a million people in the U.K., between April 2006 and December 2010."The authors looked at a very large and well-established cohort with the UK BioBank, which is a really phenomenal resource," says Stephen Juraschek, MD, research director at the Hypertension Center at Beth Israel Deaconess Medical Center in Boston. "But [the results] are largely confirmatory with what we know about these healthy lifestyle recommendations." He says the next steps should be to find out how to roll out healthier lifestyle measures to the general population."How do we improve policies to promote healthier eating and healthier food choices in the supply chain, or to ensure people are less sedentary?.

" he says. "What can we do culturally to promote those kinds of behaviors?. "By Amy Norton HealthDay ReporterWEDNESDAY, Dec.

29, 2021 (HealthDay News) -- Red-meat lovers may raise their risk of heart disease through a chain of events that plays out in the gut, a new study suggests.Many studies over the years have tied diets heavy in red and processed meats to a heightened risk of heart disease and stroke. That type of evidence does not, however, prove red meat is the problem -- or, if it is, why.The new findings offer more clues about the "why."Researchers found that particular gut bacteria, more abundant in red-meat eaters, are key in turning a dietary nutrient called carnitine into a foe. A chemical known as TMAO, which helps promote blood-clotting and clogged arteries.For the average person, the insights reinforce what's already known about heart-healthy eating, said study co-author Dr.

Stanley Hazen, who directs Cleveland Clinic's Center for Microbiome and Human Health.In particular, he pointed to the traditional Mediterranean diet, which has been shown in clinical trials to cut the risks of heart disease and stroke. That diet is high in fish, fruits and vegetables, legumes, olive oil and nuts -- and low in red meat and processed foods.The new study was published Dec. 23 in Nature Microbiology.

It is among the latest to delve into the relationship among diet, the gut microbiome and human health. "Microbiome" refers to the vast collection of bacteria and other microbes that naturally inhabit the human body, especially the gut. Research in recent years has begun to reveal just how vital those gut microbes are -- not only in digestion, but in immune system defenses, brain function and the health of the cardiovascular system.It's well-established, Hazen said, that people with diets high in red meat typically have a higher risk of heart disease and stroke than those who eat little red meat.The traditional suspect was saturated fat, found almost exclusively in animal products.

Saturated fat can boost "bad" LDL cholesterol, which contributes to cardiovascular disease.But, Hazen said, research has shown that any ill effects of saturated fat are not enough to explain the excess heart disease risks linked to heavy red-meat consumption. There had to be other mechanisms. The new findings point to one, said Lauri Wright, chair of nutrition and dietetics at the University of North Florida, in Jacksonville.There is still much to learn about the gut microbiome, said Wright, who is also a spokesperson for the Academy of Nutrition and Dietetics.

But in general, she said, diets rich in foods like vegetables, fruits and high-fiber grains help "feed" beneficial gut microbes."It still goes back to food," Wright said.Hazen, too, said he is a "big supporter" of using diet to change the gut microbiome, rather than adding certain bugs via probiotic supplements."Changing your diet changes the soil" that feeds gut microbes, he explained.The latest findings build on earlier work by Hazen and his colleagues focusing on TMAO. The chemical is generated when gut bacteria break down carnitine, a nutrient particularly abundant in red meat.The researchers had already shown that TMAO appears to raise the risk of heart disease and stroke. And in a 2019 study, they found that adding red meat to healthy people's diets for a short time boosts blood levels of TMAO.

Those levels went back down, though, when red meat was swapped for either white meat or vegetable proteins. In the latest study, looking at both humans and lab mice, the researchers found that a cluster of gut bacteria -- within a group called Emergencia timonensis -- transform carnitine into TMAO. While meat-eaters harbor a decent amount of those microbes, longtime vegetarians and vegans have very few.In the experiments with mice, the researchers found that introducing E.

Timonensis boosted TMAO levels and the blood's propensity to form clots.The researchers also analyzed stool samples from people who took part in the 2019 diet study. They found that when participants were eating a lot of red meat, their stool harbored more of the culprit E. Timonensis microbes.

When they switched to non-meat protein sources, those microbial levels dropped.There are blood tests available to measure people's TMAO levels. And Hazen said that these could potentially allow health-care providers to give patients more personal diet advice. If someone's TMAO levels were high, limiting red meat would be particularly important.

But what you take in, Wright noted, is as important as what you limit. She said that fermented foods like yogurt and kimchi, which contain certain microbes, can be good choices. But again, she stressed, overall diet is what's key in supporting a healthy gut.

More informationThe American Heart Association has advice on heart-healthy eating.SOURCES. Stanley Hazen, MD, PhD, director, Center for Microbiome and Human Health, Cleveland Clinic, Ohio. Lauri Wright, PhD, RDN, assistant professor, chair, nutrition and dietetics, University of North Florida, Jacksonville, Fla..

Dec click this site buy lasix water pills. 30, 2021 – By 2025, 10 to 20 new cell and gene therapies will likely be approved each year, according to the FDA.Great news, right?. These products could save countless lives of people living with rare genetic diseases, like Sickle Cell, Progeria, and Spina Bifida.The hefty price tag for these treatments, however, could hinder cause for celebration, according to biotechnology and policy expert Kevin Doxzen, PhD, a Hoffmann Fellow at both Arizona State University, Tempe, and the World Economic Forum.In an article published in The Conversation, he cautions that gene therapies buy lasix water pills can cost hundreds of thousands to millions of dollars.A sickle cell treatment, which is expected to be approved in the next few years, could cost a single patient around $1.85 million dollars. A Medicare program could pay around $30 million dollars each year, even if only 7% of those eligible get treated.Another example is Zolgensma, a one-time medication to treat spinal muscular atrophy, which is a disease that can cause your muscles to grow weak and decay, often leading to difficulty sitting up, walking, breathing, and swallowing. With a $2.1-million-dollar price tag, Zolgensma is the world’s most expensive drug.Raising large amounts of money for drugs like buy lasix water pills Zolgensma can be extremely taxing for those living with rare diseases and their families.Take Ayah Lundt, a young girl in Denmark highlighted in The Conversation article who was diagnosed with spinal muscular atrophy at 10 months old.

After a grueling 7 ½ months of online fundraisers and auctions from large donors around the world, her family garnered enough support to raise the $2.1 million dollars to purchase Zolgensma.For some families, however, that approach may not be as successful.So how do these life-changing drugs get in the hands of patients in need?. Creating payment models that help patients with the cost of treatment, while also keeping insurance programs and drug companies afloat, is one way, says Doxzen.In what is called “outcome-based buy lasix water pills models,” insurance could pay drug companies an initial fee, and then continue payments based on the patient’s progress after receiving treatment-- especially since costly drugs like Zolgensma aren’t guaranteed to be effective. The “Netflix model,” is another potential solution, Doxzen says.Operating like a subscription service, a state Medicaid program could pay drug companies a flat fee for unlimited access to gene therapies. This model helped create more access to hepatitis-C treatments for patients buy lasix water pills in Louisiana.Keto isn't new The Keto diet is another trendy weight-loss plan, although Susie warns that it's not all that new a concept. "This diet has been around for a while," previously going by the names of Atkins or South Beach diets, Susie said.

"I feel buy lasix water pills like it has a really great marketing manager, because every so often this diet gets rebranded." The Keto diet heavily restricts your intake of carbohydrates, while increasing your intake of fats and proteins. The goal is to reach a state of ketosis, "a metabolic state where you're burning fat for energy instead of burning carbohydrates for energy," Susie said. "Basically you're asking your body to work off of fats instead of buy lasix water pills primarily carbohydrates in the diet," Cheskin said. However, the Keto diet can be tough on a person. "To get there can be a little bit brutal," Susie said, noting that people new to the diet often suffer a few days of the buy lasix water pills "Keto flu" during which they feel foggy-headed, lethargic and headachy.

Other common side effects are disrupted sleep and constipation. "When we remove some of these foods, we're taking away key buy lasix water pills nutrients and removing a lot of fiber," which can lead to constipation, Susie said. Keto's emphasis on fats also isn't very good for your heart, Cheskin added. "In some ways, this is a heart attack diet," buy lasix water pills he said. "Eat all the bacon you want, just don't have potatoes -- well, you're eating a diet that's the opposite of what preventive cardiology would tell you to do." Folks will lose weight on Keto if they're eating less, "but you would probably obtain greater health benefit if you lose a similar amount of weight using a diet that is more healthful," Cheskin said.

Beware Whole 30 Cheskin and Susie were the most buy lasix water pills critical of the Whole 30 Program, a diet in which participants cut out added sugars, grains, legumes and dairy for a solid month. "What's a little concerning about the Whole 30 diet is this was founded by people that have limited nutrition education," Susie said. "It's extremely restrictive buy lasix water pills. For 30 days you are going to eliminate a lot of different food groups."Dec. 29, 2021 The U.S buy lasix water pills.

Centers for Disease Control and Protection is investigating two separate listeria outbreaks linked to packaged salads produced by Fresh Express and Dole, the agency said in a food safety alert. Consumers who have the buy lasix water pills products at home should throw them out, and businesses should not sell them, the CDC says. The Fresh Express recall was initiated Dec. 20 and covers salads with product codes Z324 through Z350 for all use-by dates buy lasix water pills Recalled brands include Fresh Express, Bowl &. Basket, Giant Eagle, Little Salad Bar, Marketside, O Organics, Signature Farms, Simply Nature, Weis Fresh from the Field, and Wellsley Farms Organic, the CDC said.

The U.S buy lasix water pills. Food and Drug Administration website has a full list of recalled Fresh Express products provided by the company. Routine product sampling in Michigan detected listeria buy lasix water pills in a 9-ounce bag of Fresh Express Sweet Hearts Romaine Lettuce Sweet Butter Lettuce, the Michigan Department of Agriculture and Rural Development said in a news release. Dole Fresh Vegetables Inc. Started its recall Dec buy lasix water pills.

22 for Dole-branded and private label packaged salads processed at plants in Bessemer City, N.C., and Yuma, AZ., the company said in a news release also posted on the U.S. Food and Drug Administration buy lasix water pills website. The recalled products have lot codes beginning with the letter “N” or “Y” in the upper right-hand corner of the package and have used-by dates between Nov. 30, 2021, and Jan buy lasix water pills. 8, 2022.

Some of the products are sold under the Dole, Kroger, Little Salad Bar, Marketside, Naturally buy lasix water pills Better, Nature’s Promise, and Simply Nature labels. The FDA website has a full list of recalled Dole products. Random sampling in Georgia and Michigan detected listeria in a Dole-branded Garden Salad buy lasix water pills from Bessemer City and a package of shredded iceberg lettuce from Yuma. The Bessemer City and Yuma facilities are temporarily closed for extensive cleaning, Dole said in the news release. No products from Dole plants in Springfield, OH., or Soledad, buy lasix water pills CA., are being recalled.

Springfield products have production lot codes beginning with “W” and Soledad products have a “B” production code. Listeria is a bacteria that can be found in dust, soil, animal feces, and other substances. If you eat something buy lasix water pills carrying the bacteria, it could lead to listeria , one of the main causes of food poisoning. Symptoms of listeria can include nausea, diarrhea, and vomiting. Listeria usually doesn’t lead to serious illness if you’re healthy, though you may feel sick for buy lasix water pills a day or two.

The can be particularly severe for the elderly and those with weakened immune systems, and possibly life-threatening for pregnant women and their babies.Dec. 29, 2021 -- We know a healthy lifestyle can help prevent health issues -- including cancer, heart buy lasix water pills disease, and type 2 diabetes -- but new research shows it may also lower the risk for heart disease and diabetes in people who already have had cancer.In a large study published in JACC. CardioOncology, researchers found that healthy living significantly reduced the risk of cancer, cardiovascular disease, and type 2 diabetes in a healthy population, and also lowered the risk of heart disease and type 2 diabetes (T2D) in those with a history of cancer."These findings highlight the benefits of adopting a combination of healthy behavioral practices in reducing the risk for CVD [heart disease] and T2D complications among patients with and without prevalent cancer," said the researchers, led by Zhi Cao of Tianjin Medical University’s School of Public Health in Tiagnjin, China.Healthy living was defined by five things. Not smoking, meeting guidelines for physical activity, following a healthy diet, moderate alcohol use, and buy lasix water pills moderate sleep duration. That said, the connection to alcohol consumption as part of a healthy lifestyle should be taken with caution, says Erin D.

Michos, MD, an associate professor of medicine and epidemiology and associate director of preventive cardiology at Johns Hopkins buy lasix water pills School of Medicine in Baltimore, who also co-authored an editorial published with the study.Alcohol -- even moderate use -- is a risk factor for many cancers, as well as for atrial fibrillation, or an irregular heart rhythm, she says."Its use is not endorsed as a preventive strategy by the American Heart Association or the American Society of Clinical Oncology."The researchers examined the impact of healthy living on 432,000 people ages 40 to 70 years who were enrolled in the UK BioBank, a database of genetic and health information from half a million people in the U.K., between April 2006 and December 2010."The authors looked at a very large and well-established cohort with the UK BioBank, which is a really phenomenal resource," says Stephen Juraschek, MD, research director at the Hypertension Center at Beth Israel Deaconess Medical Center in Boston. "But [the results] are largely confirmatory with what we know about these healthy lifestyle recommendations." He says the next steps should be to find out how to roll out healthier lifestyle measures to the general population."How do we improve policies to promote healthier eating and healthier food choices in the supply chain, or to ensure people are less sedentary?. " he buy lasix water pills says. "What can we do culturally to promote those kinds of behaviors?. "By Amy buy lasix water pills Norton HealthDay ReporterWEDNESDAY, Dec.

29, 2021 (HealthDay News) -- Red-meat lovers may raise their risk of heart disease through a chain of events that plays out in the gut, a new study suggests.Many studies over the years have tied diets heavy in red and processed meats to a heightened risk of heart disease and stroke. That type of evidence does not, however, prove red meat is the problem -- or, if it is, why.The new findings offer more clues about the "why."Researchers found that buy lasix water pills particular gut bacteria, more abundant in red-meat eaters, are key in turning a dietary nutrient called carnitine into a foe. A chemical known as TMAO, which helps promote blood-clotting and clogged arteries.For the average person, the insights reinforce what's already known about heart-healthy eating, said study co-author Dr. Stanley Hazen, who directs Cleveland Clinic's Center for Microbiome and Human Health.In buy lasix water pills particular, he pointed to the traditional Mediterranean diet, which has been shown in clinical trials to cut the risks of heart disease and stroke. That diet is high in fish, fruits and vegetables, legumes, olive oil and nuts -- and low in red meat and processed foods.The new study was published Dec.

23 in buy lasix water pills Nature Microbiology. It is among the latest to delve into the relationship among diet, the gut microbiome and human health. "Microbiome" refers to the vast collection of bacteria and other microbes that naturally inhabit the human body, especially buy lasix water pills the gut. Research in recent years has begun to reveal just how vital those gut microbes are -- not only in digestion, but in immune system defenses, brain function and the health of the cardiovascular system.It's well-established, Hazen said, that people with diets high in red meat typically have a higher risk of heart disease and stroke than those who eat little red meat.The traditional suspect was saturated fat, found almost exclusively in animal products. Saturated fat buy lasix water pills can boost "bad" LDL cholesterol, which contributes to cardiovascular disease.But, Hazen said, research has shown that any ill effects of saturated fat are not enough to explain the excess heart disease risks linked to heavy red-meat consumption.

There had to be other mechanisms. The new findings point to one, buy lasix water pills said Lauri Wright, chair of nutrition and dietetics at the University of North Florida, in Jacksonville.There is still much to learn about the gut microbiome, said Wright, who is also a spokesperson for the Academy of Nutrition and Dietetics. But in general, she said, diets rich in foods like vegetables, fruits and high-fiber grains help "feed" beneficial gut microbes."It still goes back to food," Wright said.Hazen, too, said he is a "big supporter" of using diet to change the gut microbiome, rather than adding certain bugs via probiotic supplements."Changing your diet changes the soil" that feeds gut microbes, he explained.The latest findings build on earlier work by Hazen and his colleagues focusing on TMAO. The chemical is generated when gut bacteria break down carnitine, a nutrient particularly abundant in red buy lasix water pills meat.The researchers had already shown that TMAO appears to raise the risk of heart disease and stroke. And in a 2019 study, they found that adding red meat to healthy people's diets for a short time boosts blood levels of TMAO.

Those levels went back down, though, when red meat was swapped for either white buy lasix water pills meat or vegetable proteins. In the latest study, looking at both humans and lab mice, the researchers found that a cluster of gut bacteria -- within a group called Emergencia timonensis -- transform carnitine into TMAO. While meat-eaters harbor a decent amount of those microbes, longtime vegetarians and vegans have very few.In the experiments with mice, the researchers found that introducing E. Timonensis boosted TMAO levels and the blood's propensity to form clots.The researchers also analyzed stool samples from people who took part in the 2019 diet study. They found that when participants were eating a lot of red meat, their stool harbored more of the culprit E.

Timonensis microbes. When they switched to non-meat protein sources, those microbial levels dropped.There are blood tests available to measure people's TMAO levels. And Hazen said that these could potentially allow health-care providers to give patients more personal diet advice. If someone's TMAO levels were high, limiting red meat would be particularly important. But what you take in, Wright noted, is as important as what you limit.

She said that fermented foods like yogurt and kimchi, which contain certain microbes, can be good choices. But again, she stressed, overall diet is what's key in supporting a healthy gut. More informationThe American Heart Association has advice on heart-healthy eating.SOURCES. Stanley Hazen, MD, PhD, director, Center for Microbiome and Human Health, Cleveland Clinic, Ohio. Lauri Wright, PhD, RDN, assistant professor, chair, nutrition and dietetics, University of North Florida, Jacksonville, Fla..

Lasix instructions

When we took lasix instructions the editorship of Evidence-Based Mental Health (EBMH) at the end of 2013, best online lasix we set two main objectives. To promote lasix instructions and embed an evidence-based medicine (EBM) approach into daily mental health clinical practice, and to get an impact factor (IF) for EBMH. Both aims have been big challenges and we have learnt a lot.EBM has been around for about 30 years now, shaping and changing the way lasix instructions we practice medicine. When Guyatt and colleagues published their seminal paper in 1992,1 EBM was described as the combination of three intersecting domains. The best available evidence, the clinical state and lasix instructions circumstances, and patient’s preferences and values.

EBM and EBMH have since continuously evolved to deepen our understanding of these three domains.The best available lasix instructions evidenceWe keep complaining about the poor quality of studies in mental health. To properly assess the effects of interventions and devices before and after regulatory approval, we all know that randomised controlled trials are the best study design.2 3 However, real-world data are crucial to shed light on key clinical questions,4 especially when adverse events5 or prognostic factors6 are investigated. It necessarily …IntroductionQuality-adjusted life years (QALYs) have been increasingly used in general medicine and in psychiatry to evaluate the impact of a disease on both the quantity and quality of life.1 One QALY is equal to 1 year in perfect health, can range down to zero (death) or may take lasix instructions negative values (worse than death). QALYs can be used to compare the burdens of various diseases, to appreciate the impact of their interventions, to help set priorities in resource allocations across different diseases and interventions and to inform personal decisions.The representative method to evaluate QALYs is the generic, preference-based measure of health including the Euro-Qol five dimensions (EQ-5D)2 3 and the SF-6D based on Short Form Survey-36 (SF-36).4 5 Of these, the EQ-5D is the most frequently used and is the preferred instrument by the National Institute of Health lasix instructions and Care Excellence in the UK. While the responsiveness of such generic measures to various mental conditions, especially severe mental illnesses, has been questioned,6 its validity and responsiveness to common lasix instructions mental disorders including depression and anxiety have been generally established.7 8However, the traditional focus of measurements in mental health has centred mainly on symptoms.

Many trials have, therefore, not administered the generic health-related quality of life measures. This has hindered comparison of impacts of mental disorders vis-à-vis other medical conditions on the one lasix instructions hand and also evaluation of values of their interventions on the other.9 10We have been collecting individual participant-level data from randomised controlled trials of internet cognitive-behavioural therapies (iCBT) for depression,11 several of which administered both symptomatologic scales and generic health status scales simultaneously. This study, lasix instructions therefore, attempts to link the depression-specific measure onto the generic measure of health in order to enable estimation of QALYs for depressive states and their changes. Such cross-walking should facilitate assessment of burden of depression at its various severity and of the impacts of its various treatments.MethodsDatabaseWe have been accumulating a data set of individual participant data of randomised controlled trials of iCBT among adults with depressive symptoms, as established by specified cut-offs on self-report scales or by diagnostic interviews.11 For this study, we have selected studies that have administered the EQ-5D and depression severity scales at baseline and at end of treatment. We excluded patients if lasix instructions they had missing data in either of the two scales at baseline or at endpoint.

We excluded studies that focused on patients with general medical disorders (eg, diabetes, glioma) and depressive symptoms.MeasuresEQ-5D-3LThe EQ-5D-3L comprises five dimensions of mobility, self-care, usual activities, pain/discomfort and anxiety/depression, each rated on three levels corresponding with 1=no problems, 2=some/moderate problems lasix instructions or 3=extreme problems/unable to do. This produces 3ˆ5=243 different health states, lasix instructions ranging from no problem at all in any dimension (11111) to severe problems on all dimensions (33333). Each of these 243 states is provided with a preference-based score, as determined through the time trade-off (TTO) technique in a sample of the general population. In TTO, respondents are asked to give lasix instructions the relative length of time in full health that they would be willing to sacrifice for the poor health states as represented by each of the 243 combinations above. The EQ-5D scores range between 1=full health and 0=death to minus values=worse than lasix instructions death bounded by −1.

The scoring algorithm for the UK is based on TTO responses of a random sample (n=2997) of noninstitutionalised adults. Over the years, value sets for EQ-5D-3L have been produced for lasix instructions many countries/regions.2 3 7Depression severity scalesWe included any validated depression severity measures. The scale scores were converted lasix instructions into the most frequently used scale, namely, the Patient Health Questionnaire-9 (PHQ-9),12 using the established conversion algorithms13 14 for the Beck Depression Inventory, second edition (BDI-II)15 or the Centre for Epidemiologic Studies Depression Scale (CES-D).16The PHQ-9 consists of the nine diagnostic criteria items of major depression from the DSM-IV, each rated on a scale between 0 and 3, making the total score range 0–27. The instrument has demonstrated excellent reliability, validity and responsiveness. The cut-offs have been proposed as 0–4, 5–9, 10–14, 15–19 and 20- for no, mild, moderate, moderately severe and severe depression, respectively.12Statistical analysesWe first calculated Spearman correlation coefficients between PHQ-9 lasix instructions and EQ-5D total scores at baseline, at end of treatment and their changes, to establish if the linking is justified.

Correlations were considered weak if scores were <0.3, moderate if scores were ≥0.3 and<0.7 and lasix instructions strong if scores were ≥0.7.17 Correlations ≥0.3 have been recommended to establish linking.18 We then applied the equipercentile linking procedure,19 which identified scores on PHQ-9 and EQ-5D or their changes with the same percentile ranks and allows for a nominal translation from PHQ-9 to EQ-5D by using their percentile values. This approach has been used successfully for scales in depression, schizophrenia or Alzheimer’s disease.14 20–22 We analysed all trials collectively rather than by trial lasix instructions to maximise the sample size, ensure variability in the included populations and attain robust estimates.We conducted a sensitivity analysis by excluding studies that require the conversion of various depression severity scores into PHQ-9.All the analyses were conducted in R V.4.0.2, with the package equate V.2.0.7.23Ethics statementThe authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Ethical approval was not required for this study as it used only deidentified patient data.FindingsIncluded studiesWe identified seven RCTs of iCBT (total n=2457), which administered validated depression scales and EQ-5D both at baseline and at endpoint (online supplemental eTable 1). Three studies included only patients with major depressive disorder (MDD), one only patients lasix instructions with subthreshold depression and the remaining three included both. All the studies administered EQ-5D-3L lasix instructions.

PHQ-9 scores were converted from the BDI-II in three studies24–26 and from the CES-D in one study.27 The mean age of the participants was 41.8 (SD=12.3) years, 66.0% (1622/2457) were women and they scored 14.0 (5.4) on PHQ-9 and 0.74 (0.20) on EQ-5D at baseline and 9.1 (6.0) and 0.79 (0.21), respectively, at endpoint. When using the standard cut-offs of the PHQ-9,12 2.4% (60/2449) suffered from no depression (PHQ-9 scores <5), 20.2% (492/2449) from subthreshold depression (5≤PHQ-9 scores <10), 33.5% (820/2449) from mild depression (10≤PHQ-9 scores <15), 26.5% (649/2449) from moderate depression (15≤PHQ-9 scores <20) and 17.3% (424/2449) from severe depression (20≤PHQ-9 scores) at baseline.Supplemental materialEquipercentile linkingSpearman’s correlation coefficient between the PHQ-9 and the EQ-5D scores was r=−0.29 at baseline, increased to r=−0.50 after intervention and was r=−0.38 for change scores.Figure 1 shows the equipercentile linking between lasix instructions PHQ-9 and EQ-5D total scores at baseline and at endpoint. Figure 2 shows the lasix instructions same between their change scores. Table 1 summarises the correspondences between lasix instructions the two scales.PHQ-9 and EQ-5D total scores at baseline and endpoint. EQ-5D,Euro-Qol Five Dimensions.

PHQ-9, PatientHealth Questionnaire-9." data-icon-position data-hide-link-title="0">Figure 1 PHQ-9 and EQ-5D total scores at baseline and lasix instructions endpoint. EQ-5D,Euro-Qol Five Dimensions lasix instructions. PHQ-9, PatientHealth Questionnaire-9.PHQ-9 change scores and EQ-5D change scores. EQ-5D, Euro-Qol Five lasix instructions Dimensions. PHQ-9, Patient lasix instructions Health Questionnaire-9." data-icon-position data-hide-link-title="0">Figure 2 PHQ-9 change scores and EQ-5D change scores.

EQ-5D,Euro-Qol Five lasix instructions Dimensions. PHQ-9, PatientHealth Questionnaire-9.View this table:Table 1 Conversion table from PHQ-9 to EQ-5D total and change scoresSensitivity analysisWhen we limited the samples to the three studies28–30 that administered PHQ-9 (total n=1375), the linking results were replicated (online supplemental eFigure 1).DiscussionThis is the first study to link a depression severity measure with the EQ-5D-3L both for total and change scores. To summarise, subthreshold depression corresponded with EQ-5D-3L index values of 0.9–0.8, mild major depression with 0.8–0.7, moderate lasix instructions depression with 0.7–0.5 and severe depression with 0.6–0.0. A five-point improvement in PHQ-9 corresponded approximately with an increase in EQ-5D-3L index values by 0.03, and a ten-point improvement can lead to an increase by approximately 0.25.A systematic review of utility values for depression31 found that the pooled mean (SD) utilities based on studies using the standard gamble as a direct valuation method were 0.69 lasix instructions (0.14) for mild, 0.52 (0.28) for moderate and 0.27 (0.26) for severe major depression. The estimates based on studies using EQ-5D as an indirect valuation method were 0.56 http://nms.langschlag.at/osterkoerbchen/ (0.16) for mild, 0.52 (0.28) for moderate and 0.25 (0.15) for severe depression.

One recent study regressed PHQ-9 on SF-6D scores among 394 patients in lasix instructions theimproving Access to Psychological Therapies (IAPT) cohort7 32 and estimated none/mild depression on PHQ-9 to be worth 0.73 SF-6D scores, moderate depression 0.65 and severe depression 0.56. Our results are largely in line with these aforementioned studies.There was lasix instructions a consistent difference of about 0.07 EQ-5D scores for the same PHQ-9 score if it represented the baseline or endpoint measurements (figure 1). This is understandable because a patient would rate their health status less satisfactory if they stayed equally symptomatic as before after the treatment and also because it means that they continued to suffer from depression for longer. It is, therefore, reasonable to use the conversion table at baseline for relatively new lasix instructions cases of depression and that at end of treatment for more chronic cases (table 1).An effect size to be typically expected after 2 months of antidepressant pharmacotherapy33 or psychotherapy27 34 over the pill placebo condition is 0.3. Given that the average SD of PHQ-9 lasix instructions in the studies was about 6, an effect size of 0.3 corresponds to a difference by two points on PHQ-9.

The differences in EQ-5D scores corresponding with the end-of-treatment PHQ-9 scores of x versus x+2, where x is between 5 and lasix instructions 15 (table 1), ranges between 0.08 and 0.13, producing an approximate average of 0.1 EQ-5D scores. If we assume that the same difference would continue for the ensuing 10 months, the gain in QALY per year would be equal to 0.09 QALY. If we assume that the difference would eventually wear out over the course of lasix instructions the year due to naturalistic improvements to be expected in the control group, the gain in QALY per year would be equal to 0.05 QALY. (See figure 3 for a schematic lasix instructions drawing to help understand the calculation of QALYs based on changing EQ-5D scores. In reality, the changes will be more smoothly curvilinear but the calculation will be similar.) Since one QALY is typically valuated at US$50 000 or 3000 Stirling pounds,35 such therapies would be cost-effective if they cost US$2500 to US$4500 (150 to 270 pounds) or less.

If a 1 day fill of generic selective serotonergic reuptake inhibitor antidepressants costs 1–3 dollars and a 1-year prescription costs US$400–1200 dollars, or if 8–16 sessions of psychotherapy lasix instructions cost US$1600–3200 dollars, both therapies would be deemed largely cost-effective. An individual’s decision, by contrast, will and should be more variable and no one can categorically reject nor require such treatments for all patients.A schematic graph showing gains in QALY due to typical pharmacotherapies lasix instructions or psychotherapies. A patient may start with PHQ-9 of 20, lasix instructions corresponding with EQ-5D index value of 0.5. Then they may improve after 2 months of antidepressant therapy to EQ-5D score of 0.9 (solid line), while they may improve to EQ-5D score of 0.8 even if on placebo (dashed line). If we assume that the same difference would continue for the ensuing 10 months while showing slow gradual improvement in both cases, the gain in QALY per year lasix instructions would be equal to 0.09 QALY.

If we assume that the difference would eventually wear out lasix instructions over the course of the year due to naturalistic improvements to be expected in the control group, the gain in QALY per year would be equal to 0.05 QALY. Please note that this is a schematic drawing for illustrative purposes. In reality, the changes will be more smoothly curvilinear but the lasix instructions calculation will be similar. EQ-5D, Euro-Qol lasix instructions Five Dimensions. PHQ-9, Patient lasix instructions Health Questionnaire-9.

QALY, quality-adjusted life years." data-icon-position data-hide-link-title="0">Figure 3 A schematic graph showing gains in QALY due to typical pharmacotherapies or psychotherapies. A patient may start with PHQ-9 of 20, corresponding with EQ-5D index value of 0.5 lasix instructions. Then they may improve after 2 lasix instructions months of antidepressant therapy to EQ-5D score of 0.9 (solid line), while they may improve to EQ-5D score of 0.8 even if on placebo (dashed line). If we assume that the same difference would continue for the ensuing 10 months while showing slow gradual improvement in both cases, the gain in QALY per year would be equal to 0.09 QALY. If we assume that the difference would eventually wear out over the course of the lasix instructions year due to naturalistic improvements to be expected in the control group, the gain in QALY per year would be equal to 0.05 QALY.

Please note that this is a schematic drawing lasix instructions for illustrative purposes. In reality, the changes will be more smoothly curvilinear but the calculation will be similar. EQ-5D,Euro-Qol Five lasix instructions Dimensions. PHQ-9, PatientHealth Questionnaire-9 lasix instructions. QALY, quality-adjustedlife years.Several caveats lasix instructions should be considered when interpreting the results.

First, our sample was limited to participants of trials of iCBT. It may be argued that the results, therefore, would not lasix instructions apply to patients with depression undergoing other therapies or in other settings. Second, the correlations between lasix instructions PHQ-9 and EQ-5D were strong enough for total scores at endpoint and for change scores to justify linking but were somewhat weaker at baseline, probably due to limited variability in PHQ-9 scores at baseline because some studies required minimum depression scores. However, the overall correspondence between PHQ-9 scores and EQ-5D had the same shape between baseline and endpoint, which will increase credibility of the linking at baseline as well. Third, we were lasix instructions able to compare PHQ-9 to EQ-5D-3L only.

The EQ-5D-5L, which measures health in five levels instead of three, has been developed to be more sensitive to change and lasix instructions to milder conditions.36 When data become available, we will need to link PHQ-9 and EQ-5D-5L to examine if we can obtain similar conversion values.Our study also has several important strengths. First, our sample included patients with subthreshold depression and major depression and from lasix instructions the community or workplace and the primary care. Furthermore, they encompassed mild through severe major depression in approximately equal proportions. Second, all the patients in lasix instructions our sample received iCBT or control interventions including care as usual. Potential side effects of different antidepressants, repetitive brain stimulation, electroconvulsive therapy and other more aggressive therapies must of course be taken into consideration when evaluating their impacts, but our estimates, arguably independent of major side effects, can better inform such lasix instructions considerations.

Finaly, unlike any prior studies, we were able to link specific PHQ-9 scores and their changes scores to EQ-5D-3L index values.Conclusion and clinical implicationsIn conclusion, we constructed a conversion table linking the EQ-5D, the representative generic preference-based measure of health status, and the PHQ-9, one of the most popular depression severity rating scale, for both its total scores and change scores. The table will enable fine-grained assessment of burden of depression at its lasix instructions various levels of severity and of impacts of its various treatments which may bring various degrees of improvement at the expense of some potential side effects.Data availability statementData are available upon reasonable request. The overall lasix instructions database used for this IPD is restricted due to data sharing agreements with the research institutes where the studies were conducted. IPD from individual studies are available from the individual study authors.Ethics statementsPatient consent for publicationNot required..

When we took buy lasix water pills the editorship of Evidence-Based Mental Health (EBMH) at the end of 2013, we set two main objectives. To promote buy lasix water pills and embed an evidence-based medicine (EBM) approach into daily mental health clinical practice, and to get an impact factor (IF) for EBMH. Both aims have been big challenges and we have learnt buy lasix water pills a lot.EBM has been around for about 30 years now, shaping and changing the way we practice medicine. When Guyatt and colleagues published their seminal paper in 1992,1 EBM was described as the combination of three intersecting domains.

The best available evidence, the clinical state and circumstances, and buy lasix water pills patient’s preferences and values. EBM and EBMH have since continuously evolved to deepen our understanding of these three domains.The best available evidenceWe keep complaining about the poor quality of buy lasix water pills studies in mental health. To properly assess the effects of interventions and devices before and after regulatory approval, we all know that randomised controlled trials are the best study design.2 3 However, real-world data are crucial to shed light on key clinical questions,4 especially when adverse events5 or prognostic factors6 are investigated. It necessarily …IntroductionQuality-adjusted life years (QALYs) have been increasingly used in general medicine and in psychiatry to evaluate the impact of a disease on both the quantity and quality of life.1 One QALY is equal to 1 year in perfect buy lasix water pills health, can range down to zero (death) or may take negative values (worse than death).

QALYs can be used to compare the burdens of various diseases, to appreciate the impact of their interventions, to help set priorities in resource allocations across different diseases and interventions and to inform personal decisions.The representative buy lasix water pills method to evaluate QALYs is the generic, preference-based measure of health including the Euro-Qol five dimensions (EQ-5D)2 3 and the SF-6D based on Short Form Survey-36 (SF-36).4 5 Of these, the EQ-5D is the most frequently used and is the preferred instrument by the National Institute of Health and Care Excellence in the UK. While the responsiveness of such buy lasix water pills generic measures to various mental conditions, especially severe mental illnesses, has been questioned,6 its validity and responsiveness to common mental disorders including depression and anxiety have been generally established.7 8However, the traditional focus of measurements in mental health has centred mainly on symptoms. Many trials have, therefore, not administered the generic health-related quality of life measures. This has hindered comparison of impacts of buy lasix water pills mental disorders vis-à-vis other medical conditions on the one hand and also evaluation of values of their interventions on the other.9 10We have been collecting individual participant-level data from randomised controlled trials of internet cognitive-behavioural therapies (iCBT) for depression,11 several of which administered both symptomatologic scales and generic health status scales simultaneously.

This study, therefore, attempts to link the depression-specific measure onto the generic measure of buy lasix water pills health in order to enable estimation of QALYs for depressive states and their changes. Such cross-walking should facilitate assessment of burden of depression at its various severity and of the impacts of its various treatments.MethodsDatabaseWe have been accumulating a data set of individual participant data of randomised controlled trials of iCBT among adults with depressive symptoms, as established by specified cut-offs on self-report scales or by diagnostic interviews.11 For this study, we have selected studies that have administered the EQ-5D and depression severity scales at baseline and at end of treatment. We excluded patients if they had missing data in either of the buy lasix water pills two scales at baseline or at endpoint. We excluded studies that focused on patients with general medical disorders (eg, diabetes, glioma) and depressive symptoms.MeasuresEQ-5D-3LThe EQ-5D-3L comprises five dimensions of mobility, buy lasix water pills self-care, usual activities, pain/discomfort and anxiety/depression, each rated on three levels corresponding with 1=no problems, 2=some/moderate problems or 3=extreme problems/unable to do.

This produces 3ˆ5=243 different health states, ranging from no problem at all in any dimension buy lasix water pills (11111) to severe problems on all dimensions (33333). Each of these 243 states is provided with a preference-based score, as determined through the time trade-off (TTO) technique in a sample of the general population. In TTO, respondents are asked to give the relative length of time in full health that they would be willing to sacrifice for the poor health states as represented by each of buy lasix water pills the 243 combinations above. The EQ-5D scores range between 1=full health and 0=death to minus values=worse buy lasix water pills than death bounded by −1.

The scoring algorithm for the UK is based on TTO responses of a random sample (n=2997) of noninstitutionalised adults. Over the years, value sets for EQ-5D-3L have been produced for many countries/regions.2 3 7Depression severity scalesWe included buy lasix water pills any validated depression severity measures. The scale scores were converted into the most frequently used scale, namely, the Patient Health Questionnaire-9 (PHQ-9),12 using the established conversion algorithms13 14 for the Beck Depression Inventory, second edition (BDI-II)15 or the Centre for Epidemiologic Studies Depression Scale (CES-D).16The PHQ-9 consists of the nine diagnostic criteria items of major buy lasix water pills depression from the DSM-IV, each rated on a scale between 0 and 3, making the total score range 0–27. The instrument has demonstrated excellent reliability, validity and responsiveness.

The cut-offs have been proposed as 0–4, 5–9, buy lasix water pills 10–14, 15–19 and 20- for no, mild, moderate, moderately severe and severe depression, respectively.12Statistical analysesWe first calculated Spearman correlation coefficients between PHQ-9 and EQ-5D total scores at baseline, at end of treatment and their changes, to establish if the linking is justified. Correlations were considered weak if scores were <0.3, moderate if scores were ≥0.3 and<0.7 and strong if scores were ≥0.7.17 Correlations ≥0.3 have been recommended to establish linking.18 We then applied the equipercentile linking procedure,19 which identified scores on PHQ-9 and EQ-5D or their changes with the same percentile ranks and allows for a nominal buy lasix water pills translation from PHQ-9 to EQ-5D by using their percentile values. This approach has been used successfully for scales in depression, schizophrenia or Alzheimer’s disease.14 20–22 We analysed all trials collectively rather than by trial to maximise the sample size, ensure variability in the included populations and attain robust estimates.We conducted a sensitivity analysis by excluding studies that require the conversion of various depression severity scores into PHQ-9.All the analyses were conducted in R V.4.0.2, with the package equate V.2.0.7.23Ethics statementThe authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national buy lasix water pills and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Ethical approval was not required for this study as it used only deidentified patient data.FindingsIncluded studiesWe identified seven RCTs of iCBT (total n=2457), which administered validated depression scales and EQ-5D both at baseline and at endpoint (online supplemental eTable 1).

Three studies included only patients with major depressive disorder (MDD), one only patients with subthreshold depression buy lasix water pills and the remaining three included both. All the buy lasix water pills studies administered EQ-5D-3L. PHQ-9 scores were converted from the BDI-II in three studies24–26 and from the CES-D in one study.27 The mean age of the participants was 41.8 (SD=12.3) years, 66.0% (1622/2457) were women and they scored 14.0 (5.4) on PHQ-9 and 0.74 (0.20) on EQ-5D at baseline and 9.1 (6.0) and 0.79 (0.21), respectively, at endpoint. When using the standard cut-offs of the PHQ-9,12 2.4% (60/2449) suffered from no depression (PHQ-9 scores <5), 20.2% (492/2449) from subthreshold depression (5≤PHQ-9 scores <10), 33.5% (820/2449) from mild depression (10≤PHQ-9 scores <15), 26.5% (649/2449) from moderate depression (15≤PHQ-9 scores <20) and 17.3% (424/2449) from severe depression (20≤PHQ-9 scores) at buy lasix water pills baseline.Supplemental materialEquipercentile linkingSpearman’s correlation coefficient between the PHQ-9 and the EQ-5D scores was r=−0.29 at baseline, increased to r=−0.50 after intervention and was r=−0.38 for change scores.Figure 1 shows the equipercentile linking between PHQ-9 and EQ-5D total scores at baseline and at endpoint.

Figure 2 shows the same between buy lasix water pills their change scores. Table 1 buy lasix water pills summarises the correspondences between the two scales.PHQ-9 and EQ-5D total scores at baseline and endpoint. EQ-5D,Euro-Qol Five Dimensions. PHQ-9, PatientHealth Questionnaire-9." data-icon-position data-hide-link-title="0">Figure 1 buy lasix water pills PHQ-9 and EQ-5D total scores at baseline and endpoint.

EQ-5D,Euro-Qol Five buy lasix water pills Dimensions. PHQ-9, PatientHealth Questionnaire-9.PHQ-9 change scores and EQ-5D change scores. EQ-5D, Euro-Qol Five buy lasix water pills Dimensions. PHQ-9, Patient buy lasix water pills Health Questionnaire-9." data-icon-position data-hide-link-title="0">Figure 2 PHQ-9 change scores and EQ-5D change scores.

EQ-5D,Euro-Qol Five buy lasix water pills Dimensions. PHQ-9, PatientHealth Questionnaire-9.View this table:Table 1 Conversion table from PHQ-9 to EQ-5D total and change scoresSensitivity analysisWhen we limited the samples to the three studies28–30 that administered PHQ-9 (total n=1375), the linking results were replicated (online supplemental eFigure 1).DiscussionThis is the first study to link a depression severity measure with the EQ-5D-3L both for total and change scores. To summarise, subthreshold depression corresponded with EQ-5D-3L index values of 0.9–0.8, mild major depression with buy lasix water pills 0.8–0.7, moderate depression with 0.7–0.5 and severe depression with 0.6–0.0. A five-point improvement in PHQ-9 corresponded approximately with an increase in EQ-5D-3L index values by 0.03, and a ten-point improvement can lead to an increase by approximately 0.25.A systematic review of utility values for depression31 found buy lasix water pills that the pooled mean (SD) utilities based on studies using the standard gamble as a direct valuation method were 0.69 (0.14) for mild, 0.52 (0.28) for moderate and 0.27 (0.26) for severe major depression.

The estimates based on studies using EQ-5D as an indirect valuation method were 0.56 (0.16) for mild, 0.52 (0.28) for moderate and 0.25 (0.15) for severe depression. One recent study regressed PHQ-9 on SF-6D scores among 394 patients in theimproving Access to Psychological Therapies (IAPT) cohort7 32 and estimated buy lasix water pills none/mild depression on PHQ-9 to be worth 0.73 SF-6D scores, moderate depression 0.65 and severe depression 0.56. Our results are largely in line with these aforementioned studies.There was a consistent difference of about 0.07 EQ-5D buy lasix water pills scores for the same PHQ-9 score if it represented the baseline or endpoint measurements (figure 1). This is understandable because a patient would rate their health status less satisfactory if they stayed equally symptomatic as before after the treatment and also because it means that they continued to suffer from depression for longer.

It is, therefore, reasonable to use the conversion table at baseline for relatively new cases of depression and that at end of treatment for more chronic cases (table 1).An effect size to be typically expected after 2 months of antidepressant pharmacotherapy33 or psychotherapy27 34 over the pill placebo buy lasix water pills condition is 0.3. Given that the average SD of PHQ-9 in the studies was about 6, an effect size of 0.3 buy lasix water pills corresponds to a difference by two points on PHQ-9. The differences in EQ-5D scores corresponding with the end-of-treatment PHQ-9 scores of x versus x+2, where buy lasix water pills x is between 5 and 15 (table 1), ranges between 0.08 and 0.13, producing an approximate average of 0.1 EQ-5D scores. If we assume that the same difference would continue for the ensuing 10 months, the gain in QALY per year would be equal to 0.09 QALY.

If we assume that the difference would eventually wear out over the course of the year due to naturalistic improvements to be buy lasix water pills expected in the control group, the gain in QALY per year would be equal to 0.05 QALY. (See figure 3 buy lasix water pills for a schematic drawing to help understand the calculation of QALYs based on changing EQ-5D scores. In reality, the changes will be more smoothly curvilinear but the calculation will be similar.) Since one QALY is typically valuated at US$50 000 or 3000 Stirling pounds,35 such therapies would be cost-effective if they cost US$2500 to US$4500 (150 to 270 pounds) or less. If a 1 day fill of generic selective serotonergic reuptake inhibitor antidepressants costs 1–3 dollars and a 1-year prescription costs US$400–1200 dollars, or if 8–16 sessions of psychotherapy cost US$1600–3200 dollars, both therapies would be deemed largely buy lasix water pills cost-effective.

An individual’s decision, by contrast, will and should be more variable and no one can categorically reject nor buy lasix water pills require such treatments for all patients.A schematic graph showing gains in QALY due to typical pharmacotherapies or psychotherapies. A patient may start with PHQ-9 of 20, corresponding with EQ-5D index buy lasix water pills value of 0.5. Then they may improve after 2 months of antidepressant therapy to EQ-5D score of 0.9 (solid line), while they may improve to EQ-5D score of 0.8 even if on placebo (dashed line). If we assume that the same difference would continue for the ensuing 10 months while showing buy lasix water pills slow gradual improvement in both cases, the gain in QALY per year would be equal to 0.09 QALY.

If we assume that the buy lasix water pills difference would eventually wear out over the course of the year due to naturalistic improvements to be expected in the control group, the gain in QALY per year would be equal to 0.05 QALY. Please note that this is a schematic drawing for illustrative purposes. In reality, the changes will be more smoothly curvilinear but buy lasix water pills the calculation will be similar. EQ-5D, Euro-Qol buy lasix water pills Five Dimensions.

PHQ-9, Patient Health Questionnaire-9 buy lasix water pills. QALY, quality-adjusted life years." data-icon-position data-hide-link-title="0">Figure 3 A schematic graph showing gains in QALY due to typical pharmacotherapies or psychotherapies. A patient may start with buy lasix water pills PHQ-9 of 20, corresponding with EQ-5D index value of 0.5. Then they may improve after 2 months of antidepressant therapy buy lasix water pills to EQ-5D score of 0.9 (solid line), while they may improve to EQ-5D score of 0.8 even if on placebo (dashed line).

If we assume that the same difference would continue for the ensuing 10 months while showing slow gradual improvement in both cases, the gain in QALY per year would be equal to 0.09 QALY. If we assume that the difference would eventually wear out over the course of the year due to naturalistic improvements to be expected in the control group, the buy lasix water pills gain in QALY per year would be equal to 0.05 QALY. Please note buy lasix water pills that this is a schematic drawing for illustrative purposes. In reality, the changes will be more smoothly curvilinear but the calculation will be similar.

EQ-5D,Euro-Qol Five buy lasix water pills Dimensions. PHQ-9, PatientHealth Questionnaire-9 buy lasix water pills. QALY, quality-adjustedlife years.Several caveats should be considered when buy lasix water pills interpreting the results. First, our sample was limited to participants of trials of iCBT.

It may be argued that the results, therefore, would not apply to patients with depression buy lasix water pills undergoing other therapies or in other settings. Second, the correlations between PHQ-9 and EQ-5D were strong enough for total scores at endpoint and for change scores to justify linking but were somewhat weaker at baseline, probably due to limited variability in PHQ-9 scores at baseline because some studies required buy lasix water pills minimum depression scores. However, the overall correspondence between PHQ-9 scores and EQ-5D had the same shape between baseline and endpoint, which will increase credibility of the linking at baseline as well. Third, we buy lasix water pills were able to compare PHQ-9 to EQ-5D-3L only.

The EQ-5D-5L, which measures health in five levels instead of three, has been developed to be more sensitive to change and to milder conditions.36 When data become available, we will need to link PHQ-9 and EQ-5D-5L to examine if we can obtain similar conversion values.Our buy lasix water pills study also has several important strengths. First, our sample included patients with subthreshold depression and major depression and from buy lasix water pills the community or workplace and the primary care. Furthermore, they encompassed mild through severe major depression in approximately equal proportions. Second, all the buy lasix water pills patients in our sample received iCBT or control interventions including care as usual.

Potential side effects of different antidepressants, repetitive brain stimulation, electroconvulsive therapy and other buy lasix water pills more aggressive therapies must of course be taken into consideration when evaluating their impacts, but our estimates, arguably independent of major side effects, can better inform such considerations. Finaly, unlike any prior studies, we were able to link specific PHQ-9 scores and their changes scores to EQ-5D-3L index values.Conclusion and clinical implicationsIn conclusion, we constructed a conversion table linking the EQ-5D, the representative generic preference-based measure of health status, and the PHQ-9, one of the most popular depression severity rating scale, for both its total scores and change scores. The table will enable fine-grained assessment of burden buy lasix water pills of depression at its various levels of severity and of impacts of its various treatments which may bring various degrees of improvement at the expense of some potential side effects.Data availability statementData are available upon reasonable request. The overall database used for this IPD is restricted due to data sharing agreements with the buy lasix water pills research institutes where the studies were conducted.

IPD from individual studies are available from the individual study authors.Ethics statementsPatient consent for publicationNot required..

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Dear Reader, Thank Propecia for sale canada you for following the buy lasix water pills Me&MyDoctor blog. I'm writing to let you know we are moving the public health stories authored by Texas physicians, residents, and medical students, and patients to the Texas Medical Association's social media channels. Be sure to follow us on all our social media accounts (Facebook, Twitter, Instagram) as well as Texas Medicine Today to access these stories and more. We look forward to seeing you there.Best, Olivia Suarez Me&My Doctor Editor.

Can lasix hurt your kidneys

SALT LAKE CITY, can lasix hurt your kidneys Nov. 09, 2021 (GLOBE NEWSWIRE) -- Health Catalyst, Inc. ("Health Catalyst," Nasdaq can lasix hurt your kidneys. HCAT), a leading provider of data and analytics technology and services to healthcare organizations, today reported financial results for the quarter ended September 30, 2021.

€œIn the third quarter of 2021, I am pleased to share that we achieved strong performance across our business, including exceeding the mid-point of our quarterly guidance for both revenue and Adjusted EBITDA,” said Dan Burton, CEO of Health Catalyst. €œIn addition can lasix hurt your kidneys to this financial and operational execution, we held our eighth annual Healthcare Analytics Summit conference in September, hosting more than 3,000 registrants representing more than 675 organizations and 18 countries. This year’s Summit was an important opportunity for Health Catalyst to continue to provide thought leadership within the healthcare data and analytics ecosystem, while further cultivating and deepening our relationships with customers and prospects.” Financial Highlights for the Three Months Ended September 30, 2021 Key Financial Metrics Three Months Ended September 30, 2021 2020 Year over Year ChangeGAAP Financial Data:(in thousands, except percentages, unaudited)Technology revenue$38,262 $27,964 37%Professional services revenue$23,475 $19,227 22%Total revenue$61,737 $47,191 31%Loss from operations$(42,249) $(23,458) (80)%Net loss$(40,014) $(27,326) (46)%Other Non-GAAP Financial Data:(1) Adjusted Technology Gross Profit$26,731 $19,115 40%Adjusted Technology Gross Margin70 % 68 % Adjusted Professional Services Gross Profit$4,696 $4,823 (3)%Adjusted Professional Services Gross Margin20 % 25 % Total Adjusted Gross Profit$31,427 $23,938 31%Total Adjusted Gross Margin51 % 51 % Adjusted EBITDA$(5,794) $(6,434) 10%_____________________ (1) These measures are not calculated in accordance with generally accepted accounting principles in the United States (GAAP). See the accompanying "Non-GAAP Financial Measures" section below for more information about these financial measures, including the limitations of such measures, and for a reconciliation of each measure to the most directly comparable measure calculated in accordance with GAAP.

Financial Outlook Health Catalyst provides forward-looking guidance on can lasix hurt your kidneys total revenue, a GAAP measure, and Adjusted EBITDA, a non-GAAP measure. For the fourth quarter of 2021, we expect. Total revenue between $61.4 million and $64.4 million, andAdjusted EBITDA between $(7.5) million and $(5.5) millionFor the full year of 2021, we expect. Total revenue between $238.6 million and $241.6 million, andAdjusted can lasix hurt your kidneys EBITDA between $(12.5) million and $(10.5) millionWe have not reconciled guidance for Adjusted EBITDA to net loss, the most directly comparable GAAP measure, and have not provided forward-looking guidance for net loss, because there are items that may impact net loss, including stock-based compensation, that are not within our control or cannot be reasonably predicted.

Quarterly Conference Call Details The company will host a conference call to review the results today, Tuesday, November 9, 2021, at 5:00 p.m. E.T. The conference call can lasix hurt your kidneys can be accessed by dialing 1-877-295-1104 for U.S. Participants, or 1-470-495-9486 for international participants, and referencing participant code 9356638.

A live audio webcast will be available online at https://ir.healthcatalyst.com/. A replay of the call will be can lasix hurt your kidneys available via webcast for on-demand listening shortly after the completion of the call, at the same web link, and will remain available for approximately 90 days. About Health Catalyst Health Catalyst is a leading provider of data and analytics technology and services to healthcare organizations committed to being the catalyst for massive, measurable, data-informed healthcare improvement. Its customers leverage can lasix hurt your kidneys the cloud-based data platform—powered by data from more than 100 million patient records and encompassing trillions of facts—as well as its analytics software and professional services expertise to make data-informed decisions and realize measurable clinical, financial, and operational improvements.

Health Catalyst envisions a future in which all healthcare decisions are data informed. Available Information Health Catalyst intends to use its Investor Relations website as a means of disclosing material non-public information and for complying with its disclosure obligations under Regulation FD. Forward-Looking Statements This release contains forward-looking statements can lasix hurt your kidneys within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995, as amended. These forward-looking statements include statements regarding our future growth, the impact of hypertension medications on our business and results of operations and our financial outlook for Q4 and fiscal year 2021.

Forward-looking statements are subject to risks and uncertainties and are based on potentially inaccurate assumptions that could cause actual results to differ materially from those expected or implied by the forward-looking statements. Actual results may differ materially from the results predicted, and reported results should not be considered as an indication of can lasix hurt your kidneys future performance. Important risks and uncertainties that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following. (i) changes in laws and regulations applicable to our business model.

(ii) changes in market or industry conditions, regulatory environment and receptivity to our technology can lasix hurt your kidneys and services. (iii) results of litigation or a security incident. (iv) the loss of one or more key customers or partners. (v) the impact of hypertension medications on can lasix hurt your kidneys our business and results of operations.

And (vi) changes to our abilities to recruit and retain qualified team members. For a detailed discussion of the risk factors that could affect our actual results, please refer to the risk factors identified in our SEC reports, including, but not limited to the Annual Report on Form 10-K for the year ended December 31, 2020 filed with the SEC on or about February 25, 2021 and the Quarterly Report on Form 10-Q for the fiscal quarter ended September 30, 2021 expected to be filed with the SEC on or about November 9, 2021. All information provided in this release and in the attachments is as of the date hereof, and we undertake can lasix hurt your kidneys no duty to update or revise this information unless required by law. Condensed Consolidated Balance Sheets(in thousands, except share and per share data, unaudited) As of September 30, As of December 31, 2021 2020Assets Current assets.

Cash and cash equivalents$275,765 $91,954 Short-term investments179,420 178,917 Accounts receivable, net47,681 48,296 Prepaid expenses and other assets12,471 10,632 Total current assets515,337 329,799 Property and equipment, net20,999 12,863 Intangible assets, net113,590 98,921 Operating lease right-of-use assets21,649 24,729 Goodwill169,659 107,822 Other assets4,279 3,606 Total assets$845,513 $577,740 Liabilities and stockholders’ equity Current liabilities. Accounts payable$4,771 $5,332 Accrued liabilities20,523 16,510 Acquisition-related consideration payable— 2,000 Deferred revenue55,332 47,145 Operating lease liabilities2,299 2,622 Contingent consideration liabilities2,601 14,427 Convertible senior notes, net177,837 — Total current liabilities263,363 88,036 Convertible senior notes, net— 168,994 Deferred can lasix hurt your kidneys revenue, net of current portion1,131 1,878 Operating lease liabilities, net of current portion21,947 23,669 Contingent consideration liabilities, net of current portion7,632 16,837 Other liabilities2,234 2,227 Total liabilities296,307 301,641 Commitments and contingencies Stockholders’ equity. Common stock, $0.001 par value. 51,863,870 and 43,376,848 shares issued and outstanding as of September 30, 2021 and December 31, 2020, respectively52 43 Additional paid-in capital1,379,032 1,001,645 Accumulated deficit(829,868) (725,650) Accumulated other comprehensive (loss) income(10) 61 Total stockholders' equity549,206 276,099 Total liabilities and stockholders’ equity$845,513 $577,740 Condensed Consolidated Statements of Operations(in thousands, except per share data, unaudited) Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 can lasix hurt your kidneys 2021 2020Revenue.

Technology$38,262 $27,964 $107,630 $78,150 Professional services23,475 19,227 69,580 57,416 Total revenue61,737 47,191 177,210 135,566 Cost of revenue, excluding depreciation and amortization. Technology(1)(2)12,094 9,045 34,766 25,148 Professional services(1)(2)20,992 15,307 55,711 46,401 Total cost of revenue, excluding depreciation and amortization33,086 24,352 90,477 71,549 Operating expenses. Sales and marketing(1)(2)20,808 14,629 53,164 40,618 Research and development(1)(2)16,385 13,390 45,254 38,539 General and administrative(1)(2)(3)23,056 13,297 60,596 31,111 Depreciation and amortization10,651 4,981 26,604 10,952 Total operating expenses70,900 46,297 185,618 121,220 Loss from operations(42,249) (23,458) (98,885) (57,203) Loss on extinguishment of debt— — — (8,514) Interest and other expense, net(4,423) (3,854) (12,082) (7,500) Loss before income taxes(46,672) (27,312) (110,967) (73,217) Income tax provision (benefit)(2)(6,658) 14 (6,749) can lasix hurt your kidneys (1,218) Net loss$(40,014) $(27,326) $(104,218) $(71,999) Net loss per share, basic and diluted$(0.82) $(0.68) $(2.27) $(1.87) Weighted-average shares outstanding used in calculating net loss per share, basic and diluted48,999 40,292 45,937 38,517 Adjusted net loss(4)$(9,048) $(8,287) (11,802) (20,110) Adjusted net loss per share, basic and diluted(4)$(0.18) $(0.21) $(0.26) $(0.52) ______________________ (1) Includes stock-based compensation expense as follows. Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020Stock-Based Compensation Expense:(in thousands) (in thousands)Cost of revenue, excluding depreciation and amortization.

Technology$533 $196 $1,481 $575 Professional services2,149 903 5,866 2,609 Sales and marketing6,098 3,233 16,848 9,724 Research and development2,510 2,025 7,443 5,987 General and administrative6,197 3,139 17,086 8,388 Total$17,487 $9,496 $48,724 $27,283 (2) Includes acquisition-related costs (benefit), net as follows. Three Months Ended September 30, Nine Months Ended September can lasix hurt your kidneys 30, 2021 2020 2021 2020Acquisition-related costs (benefit), net:(in thousands) (in thousands)Cost of revenue, excluding depreciation and amortization. Technology$30 $— $30 $— Professional services64 — 64 — Sales and marketing296 — 296 — Research and development455 — 455 — General and administrative5,672 1,963 15,942 1,666 Income tax provision (benefit)(6,829) — (6,829) — Total$(312) $1,963 $9,958 $1,666 (3) Includes non-recurring lease-related charges, as follows. Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020Non-recurring lease-related charges(in thousands) (in thousands)General and administrative$1,800 $584 $1,800 $709 (4) Includes non-GAAP adjustments to net loss.

Refer to can lasix hurt your kidneys the "Non-GAAP Financial Measures—Adjusted Net Loss Per Share" section below for further details. Condensed Consolidated Statements of Cash Flows(in thousands, unaudited) Nine Months EndedSeptember 30,Cash flows from operating activities2021 2020Net loss$(104,218) $(71,999) Adjustments to reconcile net loss to net cash used in operating activities. Depreciation and amortization26,604 10,952 Loss on extinguishment of debt— 8,514 Amortization of debt discount and issuance costs8,843 5,260 Impairment of lease-related assets1,800 — Non-cash operating lease expense3,165 2,865 Investment discount and premium amortization678 854 Provision for expected credit losses698 822 Stock-based compensation expense48,724 27,283 Deferred tax benefit(6,823) (1,280) Change in fair value of contingent consideration liabilities13,655 (1,004) Settlement of acquisition-related contingent consideration(11,766) — Other(17) 85 Change in operating assets and liabilities. Accounts receivable, net1,021 (4,450) Prepaid expenses and other assets(2,131) (2,937) Accounts payable, accrued liabilities, and other liabilities3,281 6,567 Deferred revenue6,540 (838) Operating lease liabilities(3,402) (2,701) Net cash used in operating activities(13,348) (22,007) can lasix hurt your kidneys Cash flows from investing activities Purchase of short-term investments(188,407) (163,346) Proceeds from the sale and maturity of short-term investments186,893 208,467 Acquisition of businesses, net of cash acquired(46,763) (102,471) Purchase of property and equipment(9,827) (1,320) Capitalization of internal use software(3,641) (751) Purchase of intangible assets(1,269) (1,249) Proceeds from sale of property and equipment19 10 Net cash used in investing activities(62,995) (60,660) Cash flows from financing activities Proceeds from public offering, net of discounts, commissions, and offering costs245,180 — Proceeds from convertible note securities, net of issuance costs— 222,482 Purchase of capped calls concurrent with issuance of convertible senior notes— (21,743) Repayment of credit facilities— (57,043) Proceeds from exercise of stock options17,303 29,393 Proceeds from employee stock purchase plan3,975 3,528 Payments of acquisition-related consideration(6,290) (748) Net cash provided by financing activities260,168 175,869 Effect of exchange rate on cash and cash equivalents(14) 5 Net increase in cash and cash equivalents183,811 93,207 Cash and cash equivalents at beginning of period91,954 18,032 Cash and cash equivalents at end of period$275,765 $111,239 Non-GAAP Financial Measures To supplement our financial information presented in accordance with GAAP, we believe certain non-GAAP measures, including Adjusted Gross Profit, Adjusted Gross Margin, Adjusted EBITDA, Adjusted Net Loss, and Adjusted Net Loss per share, basic and diluted, are useful in evaluating our operating performance.

For example, we exclude stock-based compensation expense because it is non-cash in nature and excluding this expense provides meaningful supplemental information regarding our operational performance and allows investors the ability to make more meaningful comparisons between our operating results and those of other companies. We use this non-GAAP financial information to evaluate our ongoing operations, as a component in determining employee bonus compensation, and for internal planning and forecasting purposes. We believe that non-GAAP can lasix hurt your kidneys financial information, when taken collectively, may be helpful to investors because it provides consistency and comparability with past financial performance. However, non-GAAP financial information is presented for supplemental informational purposes only, has limitations as an analytical tool and should not be considered in isolation or as a substitute for financial information presented in accordance with GAAP.

In addition, other companies, including companies in our industry, may calculate similarly-titled non-GAAP measures differently or may use other measures to evaluate their performance. A reconciliation is provided below for each non-GAAP financial measure to the most directly comparable financial measure stated in accordance with can lasix hurt your kidneys GAAP. Investors are encouraged to review the related GAAP financial measures and the reconciliation of these non-GAAP financial measures to their most directly comparable GAAP financial measures, and not to rely on any single financial measure to evaluate our business. Adjusted Gross Profit and Adjusted Gross Margin Adjusted Gross Profit is a non-GAAP can lasix hurt your kidneys financial measure that we define as revenue less cost of revenue, excluding depreciation and amortization, stock-based compensation, and acquisition-related costs, net.

We define Adjusted Gross Margin as our Adjusted Gross Profit divided by our revenue. We believe Adjusted Gross Profit and Adjusted Gross Margin are useful to investors as they eliminate the impact of certain non-cash expenses and allow a direct comparison of these measures between periods without the impact of non-cash expenses and certain other non-recurring operating expenses. The following is a reconciliation of revenue, the most directly comparable GAAP financial measure, to Adjusted Gross Profit, for the three can lasix hurt your kidneys months ended September 30, 2021 and 2020. Three Months Ended September 30, 2021 (in thousands, except percentages) Technology Professional Services TotalRevenue$38,262 $23,475 $61,737 Cost of revenue, excluding depreciation and amortization(12,094) (20,992) (33,086) Gross profit, excluding depreciation and amortization26,168 2,483 28,651 Add.

Stock-based compensation533 2,149 2,682 Acquisition-related costs, net(1)30 64 94 Adjusted Gross Profit$26,731 $4,696 $31,427 Gross margin, excluding depreciation and amortization68 % 11 % 46 %Adjusted Gross Margin70 % 20 % 51 %_________________________________(1) Acquisition-related costs, net impacting Adjusted Gross Profit includes deferred retention payments and post-acquisition restructuring costs incurred as part of business combinations. For additional details refer to Note 2 can lasix hurt your kidneys in our condensed consolidated financial statements. Three Months Ended September 30, 2020 (in thousands, except percentages) Technology Professional Services TotalRevenue$27,964 $19,227 $47,191 Cost of revenue, excluding depreciation and amortization(9,045) (15,307) (24,352) Gross profit, excluding depreciation and amortization18,919 3,920 22,839 Add. Stock-based compensation196 903 1,099 Adjusted Gross Profit$19,115 $4,823 $23,938 Gross margin, excluding depreciation and amortization68 % 20 % 48 %Adjusted Gross Margin68 % 25 % 51 %Adjusted EBITDA Adjusted EBITDA is a non-GAAP financial measure that we define as net loss adjusted for (i) interest and other expense, net, (ii) income tax (benefit) provision, (iii) depreciation and amortization, (iv) stock-based compensation, (v) acquisition-related costs, net, including the change in fair value of contingent consideration liabilities, and (vi) non-recurring lease-related charges.

We view acquisition-related expenses when applicable, such as transaction costs and changes in the fair value of contingent consideration liabilities that are directly related to business combinations as can lasix hurt your kidneys costs that are unpredictable, dependent upon factors outside of our control, and are not necessarily reflective of operational performance during a period. We believe Adjusted EBITDA provides investors with useful information on period-to-period performance as evaluated by management and comparison with our past financial performance and is useful in evaluating our operating performance compared to that of other companies in our industry, as this metric generally eliminates the effects of certain items that may vary from company to company for reasons unrelated to overall operating performance. The following is a reconciliation of our net loss, the most directly comparable GAAP financial measure, to Adjusted EBITDA, for the three months ended September 30, 2021 and 2020. Three Months Ended September 30, 2021 can lasix hurt your kidneys 2020 (in thousands)Net loss$(40,014) $(27,326) Add.

Interest and other expense, net4,423 3,854 Income tax (benefit) provision(6,658) 14 Depreciation and amortization10,651 4,981 Stock-based compensation17,487 9,496 Acquisition-related costs, net(1)6,517 1,963 Non-recurring lease-related charges(2)1,800 584 Adjusted EBITDA$(5,794) $(6,434) ________________________________(1) Acquisition-related costs, net impacting Adjusted EBITDA includes legal, due diligence, accounting, consulting fees, deferred retention payments, and post-acquisition restructuring costs incurred as part of business combinations, and changes in fair value of contingent consideration liabilities for potential earn-out payments. For additional details refer to Note 2 in our condensed consolidated financial statements.(2) Includes the lease-related impairment charge for the subleased portion of our corporate headquarters and duplicate rent expense incurred during the relocation of our corporate headquarters. Adjusted Net Loss Per Share Adjusted Net Loss can lasix hurt your kidneys is a non-GAAP financial measure that we define as net loss adjusted for (i) stock-based compensation, (ii) amortization of acquired intangibles, (iii) loss on extinguishment of debt, (iv) acquisition-related costs (benefit), net, including the change in fair value of contingent consideration liabilities and the deferred tax valuation allowance release from the acquisition of Twistle, (v) non-cash interest expense related to our convertible senior notes, and (vi) non-recurring lease-related charges. We believe Adjusted Net Loss provides investors with useful information on period-to-period performance as evaluated by management and comparison with our past financial performance and is useful in evaluating our operating performance compared to that of other companies in our industry, as this metric generally eliminates the effects of certain items that may vary from company to company for reasons unrelated to overall operating performance.

Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020Numerator:(in thousands, except share and per share amounts)Net loss$(40,014) $(27,326) $(104,218) $(71,999) Add. Stock-based compensation17,487 9,496 48,724 27,283 Amortization of acquired intangibles8,965 4,276 23,091 8,786 Loss on extinguishment of debt— — — 8,514 Acquisition-related costs (benefit), net(1)(312) 1,963 9,958 1,666 Non-cash interest expense can lasix hurt your kidneys related to convertible senior notes3,026 2,720 8,843 4,931 Non-recurring lease-related charges(2)1,800 584 1,800 709 Adjusted Net Loss$(9,048) $(8,287) $(11,802) $(20,110) Denominator. Weighted-average number of shares used in calculating net loss, basic and diluted48,998,548 40,292,380 45,937,227 38,517,272 Adjusted Net Loss per share, basic and diluted$(0.18) $(0.21) $(0.26) $(0.52) _____________________(1) Acquisition-related costs (benefit), net impacting Adjusted Net Loss includes legal, due diligence, accounting, consulting fees, deferred retention payments, and post-acquisition restructuring costs incurred as part of business combinations, changes in fair value of contingent consideration liabilities for potential earn-out payments, and the deferred tax valuation allowance release from the acquisition of Twistle. For additional details refer can lasix hurt your kidneys to Notes 2 and 13 in our condensed consolidated financial statements.(2) Includes the lease-related impairment charge for the subleased portion of our corporate headquarters and duplicate rent expense incurred during the relocation of our corporate headquarters.

Health Catalyst Investor Relations Contact:Adam BrownSenior Vice President, Investor Relations and FP&A+1 (855)-309-6800ir@healthcatalyst.com Health Catalyst Media Contact:Amanda HundtVice President, Corporate Communicationsamanda.hundt@healthcatalyst.com+1 (575) 491-0974SALT LAKE CITY, Oct. 27, 2021 (GLOBE NEWSWIRE) -- Health Catalyst, Inc. ("Health Catalyst", can lasix hurt your kidneys Nasdaq. HCAT), a leading provider of data and analytics technology and services to healthcare organizations, will release its 2021 third quarter operating results on Tuesday, November 9, 2021, after market close.

In conjunction, the company will host a conference call to review the results at 5 p.m. E.T. On the same day. Conference Call Details The conference call can be accessed by dialing (877) 295-1104 for U.S.

Participants, or (470) 495-9486 for international participants, and referencing participant code 9356638. A live audio webcast will be available online at https://ir.healthcatalyst.com/. A replay of the call will be available via webcast for on-demand listening shortly after the completion of the call, at the same web link, and will remain available for approximately 90 days. About Health Catalyst Health Catalyst is a leading provider of data and analytics technology and services to healthcare organizations committed to being the catalyst for massive, measurable, data-informed healthcare improvement.

Its customers leverage the cloud-based data platform—powered by data from more than 100 million patient records and encompassing trillions of facts—as well as its analytics software and professional services expertise to make data-informed decisions and realize measurable clinical, financial, and operational improvements. Health Catalyst envisions a future in which all healthcare decisions are data informed. Health Catalyst Investor Relations Contact. Adam BrownSenior Vice President, Investor Relations and FP&A+1 (855)-309-6800ir@healthcatalyst.com Health Catalyst Media Contact.

Amanda Hundt+1 (575)-491-0974amanda.hundt@healthcatalyst.com.

SALT LAKE CITY, Nov buy lasix water pills. 09, 2021 (GLOBE NEWSWIRE) -- Health Catalyst, Inc. ("Health Catalyst," buy lasix water pills Nasdaq. HCAT), a leading provider of data and analytics technology and services to healthcare organizations, today reported financial results for the quarter ended September 30, 2021.

€œIn the third quarter of 2021, I am pleased to share that we achieved strong performance across our business, including exceeding the mid-point of our quarterly guidance for both revenue and Adjusted EBITDA,” said Dan Burton, CEO of Health Catalyst. €œIn addition to this financial and buy lasix water pills operational execution, we held our eighth annual Healthcare Analytics Summit conference in September, hosting more than 3,000 registrants representing more than 675 organizations and 18 countries. This year’s Summit was an important opportunity for Health Catalyst to continue to provide thought leadership within the healthcare data and analytics ecosystem, while further cultivating and deepening our relationships with customers and prospects.” Financial Highlights for the Three Months Ended September 30, 2021 Key Financial Metrics Three Months Ended September 30, 2021 2020 Year over Year ChangeGAAP Financial Data:(in thousands, except percentages, unaudited)Technology revenue$38,262 $27,964 37%Professional services revenue$23,475 $19,227 22%Total revenue$61,737 $47,191 31%Loss from operations$(42,249) $(23,458) (80)%Net loss$(40,014) $(27,326) (46)%Other Non-GAAP Financial Data:(1) Adjusted Technology Gross Profit$26,731 $19,115 40%Adjusted Technology Gross Margin70 % 68 % Adjusted Professional Services Gross Profit$4,696 $4,823 (3)%Adjusted Professional Services Gross Margin20 % 25 % Total Adjusted Gross Profit$31,427 $23,938 31%Total Adjusted Gross Margin51 % 51 % Adjusted EBITDA$(5,794) $(6,434) 10%_____________________ (1) These measures are not calculated in accordance with generally accepted accounting principles in the United States (GAAP). See the accompanying "Non-GAAP Financial Measures" section below for more information about these financial measures, including the limitations of such measures, and for a reconciliation of each measure to the most directly comparable measure calculated in accordance with GAAP.

Financial Outlook Health Catalyst provides forward-looking guidance on total revenue, a GAAP measure, and Adjusted EBITDA, buy lasix water pills a non-GAAP measure. For the fourth quarter of 2021, we expect. Total revenue between $61.4 million and $64.4 million, andAdjusted EBITDA between $(7.5) million and $(5.5) millionFor the full year of 2021, we expect. Total revenue between $238.6 million and $241.6 million, andAdjusted EBITDA between $(12.5) million and $(10.5) millionWe have buy lasix water pills not reconciled guidance for Adjusted EBITDA to net loss, the most directly comparable GAAP measure, and have not provided forward-looking guidance for net loss, because there are items that may impact net loss, including stock-based compensation, that are not within our control or cannot be reasonably predicted.

Quarterly Conference Call Details The company will host a conference call to review the results today, Tuesday, November 9, 2021, at 5:00 p.m. E.T. The conference call can be accessed by dialing 1-877-295-1104 for buy lasix water pills U.S. Participants, or 1-470-495-9486 for international participants, and referencing participant code 9356638.

A live audio webcast will be available online at https://ir.healthcatalyst.com/. A replay of the call will be available via webcast for on-demand listening shortly after the completion of the call, at the same web link, and will remain available for approximately 90 days buy lasix water pills. About Health Catalyst Health Catalyst is a leading provider of data and analytics technology and services to healthcare organizations committed to being the catalyst for massive, measurable, data-informed healthcare improvement. Its customers leverage the cloud-based data platform—powered by data from more than 100 million patient records and encompassing trillions of facts—as well as its analytics software and professional services expertise to buy lasix water pills make data-informed decisions and realize measurable clinical, financial, and operational improvements.

Health Catalyst envisions a future in which all healthcare decisions are data informed. Available Information Health Catalyst intends to use its Investor Relations website as a means of disclosing material non-public information and for complying with its disclosure obligations under Regulation FD. Forward-Looking Statements This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, buy lasix water pills as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995, as amended. These forward-looking statements include statements regarding our future growth, the impact of hypertension medications on our business and results of operations and our financial outlook for Q4 and fiscal year 2021.

Forward-looking statements are subject to risks and uncertainties and are based on potentially inaccurate assumptions that could cause actual results to differ materially from those expected or implied by the forward-looking statements. Actual results buy lasix water pills may differ materially from the results predicted, and reported results should not be considered as an indication of future performance. Important risks and uncertainties that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following. (i) changes in laws and regulations applicable to our business model.

(ii) changes in market or industry buy lasix water pills conditions, regulatory environment and receptivity to our technology and services. (iii) results of litigation or a security incident. (iv) the loss of one or more key customers or partners. (v) the impact of hypertension medications on our business buy lasix water pills and results of operations.

And (vi) changes to our abilities to recruit and retain qualified team members. For a detailed discussion of the risk factors that could affect our actual results, please refer to the risk factors identified in our SEC reports, including, but not limited to the Annual Report on Form 10-K for the year ended December 31, 2020 filed with the SEC on or about February 25, 2021 and the Quarterly Report on Form 10-Q for the fiscal quarter ended September 30, 2021 expected to be filed with the SEC on or about November 9, 2021. All information provided in this release and in the attachments is as of the date hereof, and we undertake buy lasix water pills no duty to update or revise this information unless required by law. Condensed Consolidated Balance Sheets(in thousands, except share and per share data, unaudited) As of September 30, As of December 31, 2021 2020Assets Current assets.

Cash and cash equivalents$275,765 $91,954 Short-term investments179,420 178,917 Accounts receivable, net47,681 48,296 Prepaid expenses and other assets12,471 10,632 Total current assets515,337 329,799 Property and equipment, net20,999 12,863 Intangible assets, net113,590 98,921 Operating lease right-of-use assets21,649 24,729 Goodwill169,659 107,822 Other assets4,279 3,606 Total assets$845,513 $577,740 Liabilities and stockholders’ equity Current liabilities. Accounts payable$4,771 $5,332 Accrued liabilities20,523 16,510 Acquisition-related consideration payable— 2,000 Deferred revenue55,332 47,145 Operating lease liabilities2,299 2,622 Contingent consideration buy lasix water pills liabilities2,601 14,427 Convertible senior notes, net177,837 — Total current liabilities263,363 88,036 Convertible senior notes, net— 168,994 Deferred revenue, net of current portion1,131 1,878 Operating lease liabilities, net of current portion21,947 23,669 Contingent consideration liabilities, net of current portion7,632 16,837 Other liabilities2,234 2,227 Total liabilities296,307 301,641 Commitments and contingencies Stockholders’ equity. Common stock, $0.001 par value. 51,863,870 and 43,376,848 shares issued and outstanding as of September 30, 2021 buy lasix water pills and December 31, 2020, respectively52 43 Additional paid-in capital1,379,032 1,001,645 Accumulated deficit(829,868) (725,650) Accumulated other comprehensive (loss) income(10) 61 Total stockholders' equity549,206 276,099 Total liabilities and stockholders’ equity$845,513 $577,740 Condensed Consolidated Statements of Operations(in thousands, except per share data, unaudited) Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020Revenue.

Technology$38,262 $27,964 $107,630 $78,150 Professional services23,475 19,227 69,580 57,416 Total revenue61,737 47,191 177,210 135,566 Cost of revenue, excluding depreciation and amortization. Technology(1)(2)12,094 9,045 34,766 25,148 Professional services(1)(2)20,992 15,307 55,711 46,401 Total cost of revenue, excluding depreciation and amortization33,086 24,352 90,477 71,549 Operating expenses. Sales and marketing(1)(2)20,808 14,629 53,164 40,618 Research and development(1)(2)16,385 13,390 45,254 38,539 General and administrative(1)(2)(3)23,056 13,297 60,596 31,111 Depreciation and amortization10,651 4,981 26,604 10,952 Total operating expenses70,900 46,297 185,618 121,220 Loss from operations(42,249) (23,458) (98,885) (57,203) Loss on extinguishment of debt— — — (8,514) Interest and other expense, net(4,423) (3,854) (12,082) (7,500) Loss before income taxes(46,672) (27,312) (110,967) (73,217) Income tax provision (benefit)(2)(6,658) 14 (6,749) (1,218) Net loss$(40,014) $(27,326) $(104,218) $(71,999) Net loss per share, basic and diluted$(0.82) $(0.68) $(2.27) $(1.87) Weighted-average shares outstanding used in calculating net loss per share, basic and diluted48,999 40,292 45,937 38,517 Adjusted net loss(4)$(9,048) buy lasix water pills $(8,287) (11,802) (20,110) Adjusted net loss per share, basic and diluted(4)$(0.18) $(0.21) $(0.26) $(0.52) ______________________ (1) Includes stock-based compensation expense as follows. Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020Stock-Based Compensation Expense:(in thousands) (in thousands)Cost of revenue, excluding depreciation and amortization.

Technology$533 $196 $1,481 $575 Professional services2,149 903 5,866 2,609 Sales and marketing6,098 3,233 16,848 9,724 Research and development2,510 2,025 7,443 5,987 General and administrative6,197 3,139 17,086 8,388 Total$17,487 $9,496 $48,724 $27,283 (2) Includes acquisition-related costs (benefit), net as follows. Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020Acquisition-related costs (benefit), net:(in thousands) (in thousands)Cost of buy lasix water pills revenue, excluding depreciation and amortization. Technology$30 $— $30 $— Professional services64 — 64 — Sales and marketing296 — 296 — Research and development455 — 455 — General and administrative5,672 1,963 15,942 1,666 Income tax provision (benefit)(6,829) — (6,829) — Total$(312) $1,963 $9,958 $1,666 (3) Includes non-recurring lease-related charges, as follows. Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020Non-recurring lease-related charges(in thousands) (in thousands)General and administrative$1,800 $584 $1,800 $709 (4) Includes non-GAAP adjustments to net loss.

Refer to the "Non-GAAP Financial Measures—Adjusted Net Loss buy lasix water pills Per Share" section below for further details. Condensed Consolidated Statements of Cash Flows(in thousands, unaudited) Nine Months EndedSeptember 30,Cash flows from operating activities2021 2020Net loss$(104,218) $(71,999) Adjustments to reconcile net loss to net cash used in operating activities. Depreciation and amortization26,604 10,952 Loss on extinguishment of debt— 8,514 Amortization of debt discount and issuance costs8,843 5,260 Impairment of lease-related assets1,800 — Non-cash operating lease expense3,165 2,865 Investment discount and premium amortization678 854 Provision for expected credit losses698 822 Stock-based compensation expense48,724 27,283 Deferred tax benefit(6,823) (1,280) Change in fair value of contingent consideration liabilities13,655 (1,004) Settlement of acquisition-related contingent consideration(11,766) — Other(17) 85 Change in operating assets and liabilities. Accounts receivable, net1,021 (4,450) Prepaid expenses and other assets(2,131) (2,937) Accounts payable, accrued liabilities, and other liabilities3,281 6,567 Deferred revenue6,540 (838) Operating lease liabilities(3,402) (2,701) Net cash used in operating activities(13,348) (22,007) Cash flows from investing activities Purchase of short-term investments(188,407) (163,346) Proceeds from the sale and maturity of short-term investments186,893 208,467 Acquisition of businesses, net of cash acquired(46,763) (102,471) Purchase of property and equipment(9,827) (1,320) Capitalization of internal use software(3,641) (751) Purchase of intangible assets(1,269) (1,249) Proceeds from sale of property and equipment19 10 Net cash used in investing activities(62,995) (60,660) Cash flows from financing activities Proceeds from public offering, net of discounts, commissions, and offering costs245,180 — Proceeds from convertible note securities, net of issuance costs— 222,482 Purchase of capped calls concurrent with issuance of convertible senior notes— (21,743) Repayment of buy lasix water pills credit facilities— (57,043) Proceeds from exercise of stock options17,303 29,393 Proceeds from employee stock purchase plan3,975 3,528 Payments of acquisition-related consideration(6,290) (748) Net cash provided by financing activities260,168 175,869 Effect of exchange rate on cash and cash equivalents(14) 5 Net increase in cash and cash equivalents183,811 93,207 Cash and cash equivalents at beginning of period91,954 18,032 Cash and cash equivalents at end of period$275,765 $111,239 Non-GAAP Financial Measures To supplement our financial information presented in accordance with GAAP, we believe certain non-GAAP measures, including Adjusted Gross Profit, Adjusted Gross Margin, Adjusted EBITDA, Adjusted Net Loss, and Adjusted Net Loss per share, basic and diluted, are useful in evaluating our operating performance.

For example, we exclude stock-based compensation expense because it is non-cash in nature and excluding this expense provides meaningful supplemental information regarding our operational performance and allows investors the ability to make more meaningful comparisons between our operating results and those of other companies. We use this non-GAAP financial information to evaluate our ongoing operations, as a component in determining employee bonus compensation, and for internal planning and forecasting purposes. We believe buy lasix water pills that non-GAAP financial information, when taken collectively, may be helpful to investors because it provides consistency and comparability with past financial performance. However, non-GAAP financial information is presented for supplemental informational purposes only, has limitations as an analytical tool and should not be considered in isolation or as a substitute for financial information presented in accordance with GAAP.

In addition, other companies, including companies in our industry, may calculate similarly-titled non-GAAP measures differently or may use other measures to evaluate their performance. A reconciliation is provided below for each buy lasix water pills non-GAAP financial measure to the most directly comparable financial measure stated in accordance with GAAP. Investors are encouraged to review the related GAAP financial measures and the reconciliation of these non-GAAP financial measures to their most directly comparable GAAP financial measures, and not to rely on any single financial measure to evaluate our business. Adjusted Gross Profit and Adjusted Gross Margin Adjusted Gross Profit is a buy lasix water pills non-GAAP financial measure that we define as revenue less cost of revenue, excluding depreciation and amortization, stock-based compensation, and acquisition-related costs, net.

We define Adjusted Gross Margin as our Adjusted Gross Profit divided by our revenue. We believe Adjusted Gross Profit and Adjusted Gross Margin are useful to investors as they eliminate the impact of certain non-cash expenses and allow a direct comparison of these measures between periods without the impact of non-cash expenses and certain other non-recurring operating expenses. The following is a reconciliation of revenue, the most buy lasix water pills directly comparable GAAP financial measure, to Adjusted Gross Profit, for the three months ended September 30, 2021 and 2020. Three Months Ended September 30, 2021 (in thousands, except percentages) Technology Professional Services TotalRevenue$38,262 $23,475 $61,737 Cost of revenue, excluding depreciation and amortization(12,094) (20,992) (33,086) Gross profit, excluding depreciation and amortization26,168 2,483 28,651 Add.

Stock-based compensation533 2,149 2,682 Acquisition-related costs, net(1)30 64 94 Adjusted Gross Profit$26,731 $4,696 $31,427 Gross margin, excluding depreciation and amortization68 % 11 % 46 %Adjusted Gross Margin70 % 20 % 51 %_________________________________(1) Acquisition-related costs, net impacting Adjusted Gross Profit includes deferred retention payments and post-acquisition restructuring costs incurred as part of business combinations. For additional details refer buy lasix water pills to Note 2 in our condensed consolidated financial statements. Three Months Ended September 30, 2020 (in thousands, except percentages) Technology Professional Services TotalRevenue$27,964 $19,227 $47,191 Cost of revenue, excluding depreciation and amortization(9,045) (15,307) (24,352) Gross profit, excluding depreciation and amortization18,919 3,920 22,839 Add. Stock-based compensation196 903 1,099 Adjusted Gross Profit$19,115 $4,823 $23,938 Gross margin, excluding depreciation and amortization68 % 20 % 48 %Adjusted Gross Margin68 % 25 % 51 %Adjusted EBITDA Adjusted EBITDA is a non-GAAP financial measure that we define as net loss adjusted for (i) interest and other expense, net, (ii) income tax (benefit) provision, (iii) depreciation and amortization, (iv) stock-based compensation, (v) acquisition-related costs, net, including the change in fair value of contingent consideration liabilities, and (vi) non-recurring lease-related charges.

We view acquisition-related expenses when applicable, such as transaction costs and changes in the fair value of contingent consideration liabilities that are directly related to business combinations as costs that are unpredictable, dependent upon factors outside of our control, buy lasix water pills and are not necessarily reflective of operational performance during a period. We believe Adjusted EBITDA provides investors with useful information on period-to-period performance as evaluated by management and comparison with our past financial performance and is useful in evaluating our operating performance compared to that of other companies in our industry, as this metric generally eliminates the effects of certain items that may vary from company to company for reasons unrelated to overall operating performance. The following is a reconciliation of our net loss, the most directly comparable GAAP financial measure, to Adjusted EBITDA, for the three months ended September 30, 2021 and 2020. Three Months Ended September 30, buy lasix water pills 2021 2020 (in thousands)Net loss$(40,014) $(27,326) Add.

Interest and other expense, net4,423 3,854 Income tax (benefit) provision(6,658) 14 Depreciation and amortization10,651 4,981 Stock-based compensation17,487 9,496 Acquisition-related costs, net(1)6,517 1,963 Non-recurring lease-related charges(2)1,800 584 Adjusted EBITDA$(5,794) $(6,434) ________________________________(1) Acquisition-related costs, net impacting Adjusted EBITDA includes legal, due diligence, accounting, consulting fees, deferred retention payments, and post-acquisition restructuring costs incurred as part of business combinations, and changes in fair value of contingent consideration liabilities for potential earn-out payments. For additional details refer to Note 2 in our condensed consolidated financial statements.(2) Includes the lease-related impairment charge for the subleased portion of our corporate headquarters and duplicate rent expense incurred during the relocation of our corporate headquarters. Adjusted Net Loss Per Share Adjusted Net Loss is a non-GAAP financial measure that we define as net loss adjusted for (i) stock-based compensation, (ii) amortization of acquired intangibles, (iii) loss on extinguishment of debt, (iv) acquisition-related costs (benefit), net, including the change in fair value of contingent consideration liabilities and the deferred tax valuation allowance release from the acquisition of Twistle, (v) non-cash interest expense related to our convertible senior notes, and (vi) non-recurring lease-related charges buy lasix water pills. We believe Adjusted Net Loss provides investors with useful information on period-to-period performance as evaluated by management and comparison with our past financial performance and is useful in evaluating our operating performance compared to that of other companies in our industry, as this metric generally eliminates the effects of certain items that may vary from company to company for reasons unrelated to overall operating performance.

Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020Numerator:(in thousands, except share and per share amounts)Net loss$(40,014) $(27,326) $(104,218) $(71,999) Add. Stock-based compensation17,487 9,496 48,724 27,283 Amortization buy lasix water pills of acquired intangibles8,965 4,276 23,091 8,786 Loss on extinguishment of debt— — — 8,514 Acquisition-related costs (benefit), net(1)(312) 1,963 9,958 1,666 Non-cash interest expense related to convertible senior notes3,026 2,720 8,843 4,931 Non-recurring lease-related charges(2)1,800 584 1,800 709 Adjusted Net Loss$(9,048) $(8,287) $(11,802) $(20,110) Denominator. Weighted-average number of shares used in calculating net loss, basic and diluted48,998,548 40,292,380 45,937,227 38,517,272 Adjusted Net Loss per share, basic and diluted$(0.18) $(0.21) $(0.26) $(0.52) _____________________(1) Acquisition-related costs (benefit), net impacting Adjusted Net Loss includes legal, due diligence, accounting, consulting fees, deferred retention payments, and post-acquisition restructuring costs incurred as part of business combinations, changes in fair value of contingent consideration liabilities for potential earn-out payments, and the deferred tax valuation allowance release from the acquisition of Twistle. For additional details refer to Notes 2 and 13 in our condensed consolidated financial statements.(2) Includes the lease-related impairment charge for the subleased portion of our corporate headquarters and duplicate rent expense incurred during the relocation of our corporate headquarters.

Health Catalyst Investor Relations Contact:Adam BrownSenior Vice President, Investor Relations and FP&A+1 (855)-309-6800ir@healthcatalyst.com Health Catalyst Media Contact:Amanda HundtVice President, Corporate Communicationsamanda.hundt@healthcatalyst.com+1 (575) 491-0974SALT LAKE CITY, Oct. 27, 2021 (GLOBE NEWSWIRE) -- Health Catalyst, Inc. ("Health Catalyst", Nasdaq. HCAT), a leading provider of data and analytics technology and services to healthcare organizations, will release its 2021 third quarter operating results on Tuesday, November 9, 2021, after market close.

In conjunction, the company will host a conference call to review the results at 5 p.m. E.T. On the same day. Conference Call Details The conference call can be accessed by dialing (877) 295-1104 for U.S.

Participants, or (470) 495-9486 for international participants, and referencing participant code 9356638. A live audio webcast will be available online at https://ir.healthcatalyst.com/. A replay of the call will be available via webcast for on-demand listening shortly after the completion of the call, at the same web link, and will remain available for approximately 90 days. About Health Catalyst Health Catalyst is a leading provider of data and analytics technology and services to healthcare organizations committed to being the catalyst for massive, measurable, data-informed healthcare improvement.

Its customers leverage the cloud-based data platform—powered by data from more than 100 million patient records and encompassing trillions of facts—as well as its analytics software and professional services expertise to make data-informed decisions and realize measurable clinical, financial, and operational improvements. Health Catalyst envisions a future in which all healthcare decisions are data informed. Health Catalyst Investor Relations Contact. Adam BrownSenior Vice President, Investor Relations and FP&A+1 (855)-309-6800ir@healthcatalyst.com Health Catalyst Media Contact.

Amanda Hundt+1 (575)-491-0974amanda.hundt@healthcatalyst.com.